Issues
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Cover Image
Cover: Hypoxia increases apoptosis and alters Shh expression. Blocking Shh expression creates holoprosencephaly, which is characterised in its extreme form as cyclopia. See article by Smith et al. on page 915. - PDF Icon PDF LinkTable of contents
In This Issue
Editorial
A Model For Life
Of Mice and Men, and Medicine: an interview with Monica Justice
Monica Justice, a recently appointed Senior Editor on Disease Models & Mechanisms (DMM), is Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM). She leads several research teams that are merging mouse modeling with clinical genetics to elicit new information on disease mechanisms and to develop potential treatment strategies, with a focus on hematopoietic cancers and genetic syndromes. In this interview, Monica discusses what led her to focus on molecular, developmental and translational biology; her current work and future goals; and the reality of creating a balance between a demanding research role and life beyond the lab.
Linking academia and industry to bring drugs to the clinic: an interview with George Tidmarsh
George Tidmarsh, new Senior Editor on Disease Models & Mechanisms (DMM), is a physician with an academic science and medicine background and over two decades of industry experience at the cutting edge of biotechnology and drug development. Currently CEO of La Jolla Pharmaceutical Company Inc. as well as Consulting Associate Professor at Stanford University School of Medicine, he provides an insight into the value of industry as a conduit between academic research and patient benefit.
Clinical Puzzle
At A Glance
Reviews
Research Articles
Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome
Research Report
Corrigendum
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
