Issues
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Cover: Hypoxia increases apoptosis and alters Shh expression. Blocking Shh expression creates holoprosencephaly, which is characterised in its extreme form as cyclopia. See article by Smith et al. on page 915.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Editorial
A Model For Life
Of Mice and Men, and Medicine: an interview with Monica Justice
Monica Justice, a recently appointed Senior Editor on Disease Models & Mechanisms (DMM), is Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM). She leads several research teams that are merging mouse modeling with clinical genetics to elicit new information on disease mechanisms and to develop potential treatment strategies, with a focus on hematopoietic cancers and genetic syndromes. In this interview, Monica discusses what led her to focus on molecular, developmental and translational biology; her current work and future goals; and the reality of creating a balance between a demanding research role and life beyond the lab.
Linking academia and industry to bring drugs to the clinic: an interview with George Tidmarsh
George Tidmarsh, new Senior Editor on Disease Models & Mechanisms (DMM), is a physician with an academic science and medicine background and over two decades of industry experience at the cutting edge of biotechnology and drug development. Currently CEO of La Jolla Pharmaceutical Company Inc. as well as Consulting Associate Professor at Stanford University School of Medicine, he provides an insight into the value of industry as a conduit between academic research and patient benefit.
Clinical Puzzle
At A Glance
Reviews
Research Articles
Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome
Research Report
Corrigendum
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Grants awarded by The Company of Biologists help scientists travel, attend events and host sustainable activities. Make a note of the upcoming application deadlines and find out more about the grants on offer:
DMM Conference Travel Grants
17 May 2021
Sustainable Conferencing Grants
17 May 2021
Travelling Fellowships
31 May 2021
Scientific Meeting Grants
4 June 2021
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.
