Issues
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Cover image
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Cover: Hypoxia increases apoptosis and alters Shh expression. Blocking Shh expression creates holoprosencephaly, which is characterised in its extreme form as cyclopia. See article by Smith et al. on page 915.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Editorial
A Model For Life
Of Mice and Men, and Medicine: an interview with Monica Justice
Monica Justice, a recently appointed Senior Editor on Disease Models & Mechanisms (DMM), is Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM). She leads several research teams that are merging mouse modeling with clinical genetics to elicit new information on disease mechanisms and to develop potential treatment strategies, with a focus on hematopoietic cancers and genetic syndromes. In this interview, Monica discusses what led her to focus on molecular, developmental and translational biology; her current work and future goals; and the reality of creating a balance between a demanding research role and life beyond the lab.
Linking academia and industry to bring drugs to the clinic: an interview with George Tidmarsh
George Tidmarsh, new Senior Editor on Disease Models & Mechanisms (DMM), is a physician with an academic science and medicine background and over two decades of industry experience at the cutting edge of biotechnology and drug development. Currently CEO of La Jolla Pharmaceutical Company Inc. as well as Consulting Associate Professor at Stanford University School of Medicine, he provides an insight into the value of industry as a conduit between academic research and patient benefit.
Clinical Puzzle
At A Glance
Reviews
Research Articles
Norepinephrine transporter variant A457P knock-in mice display key features of human postural orthostatic tachycardia syndrome
Research Report
Corrigendum
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens

We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
Louis Pasteur continues to shape the future of microbiology

To mark the 200th anniversary of the birth of Louis Pasteur, our Editorial Board member Serge Mostowy reflects on Pasteur’s legacy, and we interview Pascale Cossart, Head of the Bacteria-Cell Interactions Unit at Institut Pasteur.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Live imaging adult disease processes

The optical transparency of zebrafish larvae facilitates live imaging, but this transparency is not maintained into adulthood. To address this, Pui-Ying Lam’s Resource Article demonstrates the feasibility of imaging adult Danionella cerebrum. This article has been highlighted as our Editor’s Choice by Kristen Kwan.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.