Issues
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Cover image
Cover Image
Cover: Psat1 null (left) and wild-type (right) mouse embryos produced by the Wellcome Trust Sanger Institute as part of a global effort by the International Knockout Mouse Consortium (IKMC) to knock out each gene in the mouse genome. ÔDeciphering the Mechanisms of Developmental DisordersÕ is a new programme using high-resolution 3D reconstructions to help phenotype embryos from IKMC knockout lines (such as Psat1) that are embryonic lethal. See Editorial by Mohun et al. on page 562. - PDF Icon PDF LinkTable of contents
In This Issue
Editorials
Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice
A Model For Life
Bench to bedside with fruit flies: an interview with Ross Cagan
Ross Cagan, new Editor-in-Chief of Disease Models & Mechanisms (DMM), is a developmental and translational biology researcher with expertise in using fruit fly models. Based at the Icahn School of Medicine at Mount Sinai, he holds professorships in Developmental and Regenerative Biology, Oncological Sciences and Ophthalmology. He is also Associate Dean of the Graduate School for Biological Sciences and co-founder of Medros, Inc. In this interview, he recalls the events and mentors that helped shape his career, explains why he loves flies, and outlines his vision for DMM.
Special Article
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
Review
Research Articles
Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich’s ataxia
Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
Research Reports
Resource Articles
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru
Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
