Issues
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Cover image
Cover Image
Cover: Psat1 null (left) and wild-type (right) mouse embryos produced by the Wellcome Trust Sanger Institute as part of a global effort by the International Knockout Mouse Consortium (IKMC) to knock out each gene in the mouse genome. ÔDeciphering the Mechanisms of Developmental DisordersÕ is a new programme using high-resolution 3D reconstructions to help phenotype embryos from IKMC knockout lines (such as Psat1) that are embryonic lethal. See Editorial by Mohun et al. on page 562. - PDF Icon PDF LinkTable of contents
In This Issue
Editorials
Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice
A Model For Life
Bench to bedside with fruit flies: an interview with Ross Cagan
Ross Cagan, new Editor-in-Chief of Disease Models & Mechanisms (DMM), is a developmental and translational biology researcher with expertise in using fruit fly models. Based at the Icahn School of Medicine at Mount Sinai, he holds professorships in Developmental and Regenerative Biology, Oncological Sciences and Ophthalmology. He is also Associate Dean of the Graduate School for Biological Sciences and co-founder of Medros, Inc. In this interview, he recalls the events and mentors that helped shape his career, explains why he loves flies, and outlines his vision for DMM.
Special Article
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
Review
Research Articles
Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich’s ataxia
Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
Research Reports
Resource Articles
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
