Issues
-
Cover image
Cover Image
Cover: Psat1 null (left) and wild-type (right) mouse embryos produced by the Wellcome Trust Sanger Institute as part of a global effort by the International Knockout Mouse Consortium (IKMC) to knock out each gene in the mouse genome. ÔDeciphering the Mechanisms of Developmental DisordersÕ is a new programme using high-resolution 3D reconstructions to help phenotype embryos from IKMC knockout lines (such as Psat1) that are embryonic lethal. See Editorial by Mohun et al. on page 562. - PDF Icon PDF LinkTable of contents
In This Issue
Editorials
Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice
A Model For Life
Bench to bedside with fruit flies: an interview with Ross Cagan
Ross Cagan, new Editor-in-Chief of Disease Models & Mechanisms (DMM), is a developmental and translational biology researcher with expertise in using fruit fly models. Based at the Icahn School of Medicine at Mount Sinai, he holds professorships in Developmental and Regenerative Biology, Oncological Sciences and Ophthalmology. He is also Associate Dean of the Graduate School for Biological Sciences and co-founder of Medros, Inc. In this interview, he recalls the events and mentors that helped shape his career, explains why he loves flies, and outlines his vision for DMM.
Special Article
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening
Review
Research Articles
Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich’s ataxia
Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
Research Reports
Resource Articles
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
