Issues
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Cover: Cross-section of a complex atherosclerotic lesion showing a large necrotic core, neovascularization and intraplaque haemorrhage. Such pathological features, previously described in human vulnerable plaque underlying acute coronary syndromes, can be consistently reproduced in a novel mouse model of complex atherosclerosis. See article by Najafi et al. on page 323.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Clinical Puzzle
Special Article
Reviews
Research Articles
Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm
Phenotypic overlap in the contribution of individual genes to CNV pathogenicity revealed by cross-species computational analysis of single-gene mutations in humans, mice and zebrafish
Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma
TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3
Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats
Research Reports
Resource Article
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Call for new preLighters
preLights is the preprint highlighting community supported by The Company of Biologists. At the heart of preLights are our preLighters: early-career researchers who select and write about interesting new preprints for the research community. We are currently looking for new preLighters to join our team. Find out more and apply here.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
