Issues
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Cover image
Cover Image
Cover: Consistent left-right patterning of the heart and viscera is a crucial part of embryogenesis. The cover shows a ventral view of the Xenopus tadpole, with pseudocolouring that reveals the asymmetric positions and morphogenesis of the gut (yellow), heart (pink) and gall bladder (green); the embryo on the left is normal, whereas its mirror image on the right depicts one with situs inversus. Xenopus is an important model organism for the study of developmental asymmetries because work in this system has most clearly revealed the molecular pathways that align the left-right axis shortly after fertilisation. Because errors of laterality form a common class of birth defects, understanding the mechanisms and timing at which left-right asymmetry is initiated is essential for human health. See article by Vandenberg et al. on page 261. - PDF Icon PDF LinkTable of contents
In This Issue
Journal Club
Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state
Summary of and comment on a recent Cell Stem Cell paper entitled ‘Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells’ (Ashton et al., 2012).
A Model For Life
Driving change in tuberculosis research: an interview with Anne O’Garra
Anne O’Garra is Head of the Division of Immunoregulation at the MRC National Institute for Medical Research (NIMR) in Mill Hill, London. In this interview, she recounts the excitement of her early career discoveries on cytokines and T-cell differentiation, and discusses progress on tuberculosis research by her group and multiple collaborators.
Clinical Puzzle
Reviews
Research Articles
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
Research Report
Resource Article
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology

Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru




Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.