Issues
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Cover image
Cover Image
Cover: Consistent left-right patterning of the heart and viscera is a crucial part of embryogenesis. The cover shows a ventral view of the Xenopus tadpole, with pseudocolouring that reveals the asymmetric positions and morphogenesis of the gut (yellow), heart (pink) and gall bladder (green); the embryo on the left is normal, whereas its mirror image on the right depicts one with situs inversus. Xenopus is an important model organism for the study of developmental asymmetries because work in this system has most clearly revealed the molecular pathways that align the left-right axis shortly after fertilisation. Because errors of laterality form a common class of birth defects, understanding the mechanisms and timing at which left-right asymmetry is initiated is essential for human health. See article by Vandenberg et al. on page 261. - PDF Icon PDF LinkTable of contents
In This Issue
Journal Club
Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state
Summary of and comment on a recent Cell Stem Cell paper entitled ‘Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells’ (Ashton et al., 2012).
A Model For Life
Driving change in tuberculosis research: an interview with Anne O’Garra
Anne O’Garra is Head of the Division of Immunoregulation at the MRC National Institute for Medical Research (NIMR) in Mill Hill, London. In this interview, she recounts the excitement of her early career discoveries on cytokines and T-cell differentiation, and discusses progress on tuberculosis research by her group and multiple collaborators.
Clinical Puzzle
Reviews
Research Articles
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
Research Report
Resource Article
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
