Issues
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Cover image
Cover Image
Cover: Consistent left-right patterning of the heart and viscera is a crucial part of embryogenesis. The cover shows a ventral view of the Xenopus tadpole, with pseudocolouring that reveals the asymmetric positions and morphogenesis of the gut (yellow), heart (pink) and gall bladder (green); the embryo on the left is normal, whereas its mirror image on the right depicts one with situs inversus. Xenopus is an important model organism for the study of developmental asymmetries because work in this system has most clearly revealed the molecular pathways that align the left-right axis shortly after fertilisation. Because errors of laterality form a common class of birth defects, understanding the mechanisms and timing at which left-right asymmetry is initiated is essential for human health. See article by Vandenberg et al. on page 261. - PDF Icon PDF LinkTable of contents
In This Issue
Journal Club
Modelling how initiating and transforming oncogenes cooperate to produce a leukaemic cell state
Summary of and comment on a recent Cell Stem Cell paper entitled ‘Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells’ (Ashton et al., 2012).
A Model For Life
Driving change in tuberculosis research: an interview with Anne O’Garra
Anne O’Garra is Head of the Division of Immunoregulation at the MRC National Institute for Medical Research (NIMR) in Mill Hill, London. In this interview, she recounts the excitement of her early career discoveries on cytokines and T-cell differentiation, and discusses progress on tuberculosis research by her group and multiple collaborators.
Clinical Puzzle
Reviews
Research Articles
A zebrafish model of congenital disorders of glycosylation with phosphomannose isomerase deficiency reveals an early opportunity for corrective mannose supplementation
Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγnull mice engrafted with human peripheral blood mononuclear cells
Research Report
Resource Article
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery
We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review
Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
Propose a new Workshop for 2027
We are currently seeking proposals for Workshops to be held in 2027. As one of the scientific organisers of a The Company of Biologists Workshop, your involvement will be focused on interdisciplinary, cutting-edge science and promoting new partnerships and collaborations. We focus on the logistics. Are you thinking about proposing a topic for one of our Workshops? Apply by Friday 30 May 2025.
