Issues
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Cover image
Cover Image
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Cover: Magnetic resonance imaging (MRI) of a stroke in the territory of the middle cerebral artery (MCA) in a mouse (top) and human (bottom). Images are oriented from rostral (left image) to caudal (right image). The mouse images show typical stroke propagation at 24 hours after 1 hour of middle cerebral artery occlusion (MCAO). Cortical and sub-cortical lesions can be seen, corresponding to a severe human stroke. The lower panel shows the stroke of a 65-year-old male patient in the territory of the right MCA. Mouse MRI images are courtesy of Odilo Engel (Charité, Berlin). See Clinical Puzzle by Mergenthaler and Meisel on page 718.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Finding NECA: zebrafish screen identifies key signalling pathway in β-cell regeneration
Summary of and comment on a recent Cell Metabolism paper entitled ‘Adenosine signaling promotes regeneration of pancreatic β cells in vivo’ (Andersson et al., 2012).
Lactate-starved neurons in ALS
Summary and comment on a recent Nature article entitled ‘Oligodendroglia metabolically support axons and contribute to neurodegeneration’ (Lee et al., 2012).
A Model For Life
Synergy in science: an interview with Neal Copeland and Nancy Jenkins
Neal Copeland and Nancy Jenkins – partners in the lab and in life – are world leaders in cancer research, mouse genetics and developmental genetics. In this interview, they recall the adventure of their joint career and discuss their views on current challenges in cancer research.
Clinical Puzzle
Primer
Special Article
Preclinical research in Rett syndrome: setting the foundation for translational success
Perspective
Commentaries
Research Articles
Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models
Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich’s ataxia
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development
Research Reports
Resource Article
Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Call for new preLighters
preLights is the preprint highlighting community supported by The Company of Biologists. At the heart of preLights are our preLighters: early-career researchers who select and write about interesting new preprints for the research community. We are currently looking for new preLighters to join our team. Find out more and apply here.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
