Issues
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Cover image
Cover Image
Cover: Magnetic resonance imaging (MRI) of a stroke in the territory of the middle cerebral artery (MCA) in a mouse (top) and human (bottom). Images are oriented from rostral (left image) to caudal (right image). The mouse images show typical stroke propagation at 24 hours after 1 hour of middle cerebral artery occlusion (MCAO). Cortical and sub-cortical lesions can be seen, corresponding to a severe human stroke. The lower panel shows the stroke of a 65-year-old male patient in the territory of the right MCA. Mouse MRI images are courtesy of Odilo Engel (Charité, Berlin). See Clinical Puzzle by Mergenthaler and Meisel on page 718. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Finding NECA: zebrafish screen identifies key signalling pathway in β-cell regeneration
Summary of and comment on a recent Cell Metabolism paper entitled ‘Adenosine signaling promotes regeneration of pancreatic β cells in vivo’ (Andersson et al., 2012).
Lactate-starved neurons in ALS
Summary and comment on a recent Nature article entitled ‘Oligodendroglia metabolically support axons and contribute to neurodegeneration’ (Lee et al., 2012).
A Model For Life
Synergy in science: an interview with Neal Copeland and Nancy Jenkins
Neal Copeland and Nancy Jenkins – partners in the lab and in life – are world leaders in cancer research, mouse genetics and developmental genetics. In this interview, they recall the adventure of their joint career and discuss their views on current challenges in cancer research.
Clinical Puzzle
Primer
Special Article
Preclinical research in Rett syndrome: setting the foundation for translational success
Perspective
Commentaries
Research Articles
Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models
Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich’s ataxia
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development
Research Reports
Resource Article
Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
