Issues
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Cover image
Cover Image
Cover: Magnetic resonance imaging (MRI) of a stroke in the territory of the middle cerebral artery (MCA) in a mouse (top) and human (bottom). Images are oriented from rostral (left image) to caudal (right image). The mouse images show typical stroke propagation at 24 hours after 1 hour of middle cerebral artery occlusion (MCAO). Cortical and sub-cortical lesions can be seen, corresponding to a severe human stroke. The lower panel shows the stroke of a 65-year-old male patient in the territory of the right MCA. Mouse MRI images are courtesy of Odilo Engel (Charité, Berlin). See Clinical Puzzle by Mergenthaler and Meisel on page 718. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Finding NECA: zebrafish screen identifies key signalling pathway in β-cell regeneration
Summary of and comment on a recent Cell Metabolism paper entitled ‘Adenosine signaling promotes regeneration of pancreatic β cells in vivo’ (Andersson et al., 2012).
Lactate-starved neurons in ALS
Summary and comment on a recent Nature article entitled ‘Oligodendroglia metabolically support axons and contribute to neurodegeneration’ (Lee et al., 2012).
A Model For Life
Synergy in science: an interview with Neal Copeland and Nancy Jenkins
Neal Copeland and Nancy Jenkins – partners in the lab and in life – are world leaders in cancer research, mouse genetics and developmental genetics. In this interview, they recall the adventure of their joint career and discuss their views on current challenges in cancer research.
Clinical Puzzle
Primer
Special Article
Preclinical research in Rett syndrome: setting the foundation for translational success
Perspective
Commentaries
Research Articles
Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models
Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich’s ataxia
Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development
Research Reports
Resource Article
Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Register your interest for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease. Find more information here.
A new call for papers is underway
Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Adult zebrafish as advanced models of human disease
Editor-in-Chief Liz Patton and Editorial Board member Rich White discuss the unique advantages of adult zebrafish for studying human disease biology. Read the Open Access Editorial here.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Disease Models & Mechanisms a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
