Issues
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Cover Image
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Cover: Photomicrograph of ileal tissue from an infant born at 29.3 weeks gestation who developed spontaneous intestinal perforation requiring ileal resection. Tissue is stained for Paneth cells using Lendrum's phloxine-tartrazine staining. Positive cells contain dark red granules and are located at the base of the intestinal crypts. See article by Zhang et al. on page 522.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Maple syrup urine disease: new insights from a zebrafish model
Summary and comment on a recent Disease Models & Mechanisms paper entitled ‘Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease’ (Friedrich et al., 2012).
A Model For Life
Thoughts of a retired scientist: an interview with Martin Raff
Martin Raff is an Emeritus Professor at University College London (UCL), where he worked for more than 30 years on various aspects of immunology, cell biology and neurobiology until his retirement in 2002. In this interview, he recounts the thrill of his first few years in science, and discusses his current fascination with the fast-moving field of neuropsychiatric disorders.
Commentary
Perspectives
Research Articles
Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction
Research Reports
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Grants awarded by The Company of Biologists help scientists travel, attend events and host sustainable activities. Make a note of the upcoming application deadlines and find out more about the grants on offer:
DMM Conference Travel Grants
17 May 2021
Sustainable Conferencing Grants
17 May 2021
Travelling Fellowships
31 May 2021
Scientific Meeting Grants
4 June 2021
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.
