Issues
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Cover Image
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Cover: Photomicrograph of ileal tissue from an infant born at 29.3 weeks gestation who developed spontaneous intestinal perforation requiring ileal resection. Tissue is stained for Paneth cells using Lendrum's phloxine-tartrazine staining. Positive cells contain dark red granules and are located at the base of the intestinal crypts. See article by Zhang et al. on page 522.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Maple syrup urine disease: new insights from a zebrafish model
Summary and comment on a recent Disease Models & Mechanisms paper entitled ‘Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease’ (Friedrich et al., 2012).
A Model For Life
Thoughts of a retired scientist: an interview with Martin Raff
Martin Raff is an Emeritus Professor at University College London (UCL), where he worked for more than 30 years on various aspects of immunology, cell biology and neurobiology until his retirement in 2002. In this interview, he recounts the thrill of his first few years in science, and discusses his current fascination with the fast-moving field of neuropsychiatric disorders.
Commentary
Perspectives
Research Articles
Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction
Research Reports
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
