Issues
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Cover image
Cover Image
Cover: Photomicrograph of ileal tissue from an infant born at 29.3 weeks gestation who developed spontaneous intestinal perforation requiring ileal resection. Tissue is stained for Paneth cells using Lendrum's phloxine-tartrazine staining. Positive cells contain dark red granules and are located at the base of the intestinal crypts. See article by Zhang et al. on page 522. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
Maple syrup urine disease: new insights from a zebrafish model
Summary and comment on a recent Disease Models & Mechanisms paper entitled ‘Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease’ (Friedrich et al., 2012).
A Model For Life
Thoughts of a retired scientist: an interview with Martin Raff
Martin Raff is an Emeritus Professor at University College London (UCL), where he worked for more than 30 years on various aspects of immunology, cell biology and neurobiology until his retirement in 2002. In this interview, he recounts the thrill of his first few years in science, and discusses his current fascination with the fast-moving field of neuropsychiatric disorders.
Commentary
Perspectives
Research Articles
Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction
Research Reports
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
A new call for papers is underway
Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Adult zebrafish as advanced models of human disease
Editor-in-Chief Liz Patton and Editorial Board member Rich White discuss the unique advantages of adult zebrafish for studying human disease biology. Read the Open Access Editorial here.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Disease Models & Mechanisms a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
