Issues
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Cover image
Cover Image
Cover: Activity of the AcP10 enhancer in a mouse prostate tumour. AcP10 is located in the 8q24 genomic region, a gene desert that has a highly significant association with prostate cancer risk. Shown is the expression of a transgene consisting of the AcP10 element driving lacZ (red) in a prostate tumour induced by prostate-specific inactivation of Pten. The transgene is expressed in a subset of lumenal epithelial cells (marked with CK8; green). Nuclei are stained blue. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Editorial
Journal Club
From white to brown fat through the PGC-1α-dependent myokine irisin: implications for diabetes and obesity
Summary and comment on a recent Nature paper entitled ‘A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis’ (Boström et al., 2012).
A Model For Life
Changing the practice of medicine: an interview with Mark Fishman
Mark Fishman has served as President of the Novartis Institutes for BioMedical Research (NIBR) since 2002, and in a former academic role was among the first to develop the zebrafish system for studying development and disease. Here, he recalls what it was like to ride the first real wave of zebrafish research, discusses industry-academia collaborations and provides a current perspective on drug development.
Perspectives
Podcast
Research Articles
Resource Articles
Research Report
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
About us
Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
