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Volume 5, Issue 1

January 2012

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Cover image

Cover Image

Cover: Histological section of the cartilage endplate including the annulus fibrosus and underlying vertebral bone from a 1-year-old mouse specimen, stained with Safranin-O/Fast Green. See article by McCann et al. on page 73.
Table of contents

ISSN 1754-8403

EISSN 1754-8411

In this issue

In This Issue
Research Highlights
Editorial
A Model For Life
Clinical Puzzle
Special Article
Commentaries
Perspectives
Podcast
Research Articles
Research Report

In This Issue

Research Highlights

Identifying candidate ALS-associated genes in yeast

Extract

View articletitled, Identifying candidate ALS-associated genes in yeast

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Atherosclerosis: visualising oxidised LDL in zebrafish

Extract

View articletitled, Atherosclerosis: visualising oxidised LDL in zebrafish

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Functionally repairing complex synaptic circuitry

Extract

View articletitled, Functionally repairing complex synaptic circuitry

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Two routes to autism phenotypes via mGluR5

Extract

View articletitled, Two routes to autism phenotypes via mGluR5

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Editorial

The NIH Undiagnosed Diseases Program: bonding scientists and clinicians

William A. Gahl,Cornelius F. Boerkoel,Manfred Boehm

Abstract

View articletitled, The NIH Undiagnosed Diseases Program: bonding scientists and clinicians

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A Model For Life

Breaking down barriers to clinical translation: an interview with Laurie Glimcher

Laurie Glimcher is a physician-scientist with a true passion for research. In this interview, she discusses her early career, key issues in successful clinical translation and her move to become Dean of Weill Cornell Medical College in Manhattan.

Extract

View articletitled, Breaking down barriers to clinical translation: an interview with Laurie Glimcher

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Clinical Puzzle

Preeclampsia: multiple approaches for a multifactorial disease

Kathleen A. Pennington,Jessica M. Schlitt,Daniel L. Jackson,Laura C. Schulz,Danny J. Schust

Abstract

View articletitled, Preeclampsia: multiple approaches for a multifactorial disease

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Special Article

Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice

Paul N. Schofield,Peter Vogel,Georgios V. Gkoutos,John P. Sundberg

Abstract

View articletitled, Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice

Supplementary information

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Commentaries

Modeling psychiatric disorders through reprogramming

Kristen J. Brennand,Fred H. Gage

Abstract

View articletitled, Modeling psychiatric disorders through reprogramming

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Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

Vinita A. Hajeri,James F. Amatruda

Abstract

View articletitled, Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms

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Perspectives

A model 450 million years in the making: zebrafish and vertebrate immunity

Stephen A. Renshaw,Nikolaus S. Trede

Abstract

View articletitled, A model 450 million years in the making: zebrafish and vertebrate immunity

Supplementary information

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Deconstructing host-pathogen interactions in Drosophila

Ethan Bier,Annabel Guichard

Abstract

View articletitled, Deconstructing host-pathogen interactions in Drosophila

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Podcast

January 2012 DMM Podcast: histopathology in high-throughput phenotyping of mutant mice

Abstract

View articletitled, January 2012 DMM Podcast: histopathology in high-throughput phenotyping of mutant mice

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Research Articles

An inducible kras^V12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

Anh Tuan Nguyen,Alexander Emelyanov,Chor Hui Vivien Koh,Jan M. Spitsbergen,Serguei Parinov,Zhiyuan Gong

Abstract

View articletitled, An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

Supplementary information

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Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

Matthew R. McCann,Owen J. Tamplin,Janet Rossant,Cheryle A. Séguin

Abstract

View articletitled, Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

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Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

Catherine Hambly,Jacqueline S. Duncan,Zoë A. Archer,Kim M. Moar,Julian G. Mercer,John R. Speakman

Abstract

View articletitled, Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

Supplementary information

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A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

Stefanie W. Leacock,Audrey N. Basse,Garvin L. Chandler,Anne M. Kirk,Dinesh Rakheja,James F. Amatruda

Abstract

View articletitled, A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis

Supplementary information

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A multiparametric approach to monitor the effects of γ-secretase inhibition along the whole intestinal tract

Laure Droy-Dupré,Mickaël Vallée,Céline Bossard,Christian L. Laboisse,Anne Jarry

Abstract

View articletitled, A multiparametric approach to monitor the effects of γ-secretase inhibition along the whole intestinal tract

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The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

Pishan Chang,Benoit Orabi,Rania M. Deranieh,Manik Dham,Oliver Hoeller,Jakob A. Shimshoni,Boris Yagen,Meir Bialer,Miriam L. Greenberg,Matthew C. Walker,Robin S. B. Williams

Abstract

View articletitled, The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium

Supplementary information

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Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

Barbara Ahlemeyer,Magdalena Gottwald,Eveline Baumgart-Vogt

Abstract

View articletitled, Deletion of a single allele of the Pex11β gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

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Research Report

Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy

Erica S. Chevalier-Larsen,Diane E. Merry

Abstract

View articletitled, Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy

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Email alerts

Accepted manuscripts alert

Table of contents alert

Latest published articles alert

Accepted manuscripts

Sodium butyrate, a pan-histone deacetylase inhibitor, does not protect spinal motor neurons from AMPA-induced excitotoxic degeneration in vivo

Mara Prior-González, Rafael Lazo-Gómez, Ricardo Tapia

Identification of HDAC inhibitors as neutrophil recruitment modulators in zebrafish using a chemical library screen

Sijia Fan, Jinlong Jiang, Huan Zhang, Cuihong Wang, Shang Kong, Tingting Zhao, Ling Meng, Yang Liu, Jingjing Qin, Xiuqin Rong, Zhenting He, Qinke He, Ke He, Ketong Chen, Ling Lei, Xinyu Hai, Hong Nie, Chunguang Ren

Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice

Jie Gao, Shumei Ren, Gabrielle Choonoo, Guoying Chen, Davor Frleta, Jun Zhong, Namita Gupta, Prachi Sharma, Adelekan Oyejide, Gurinder S. Atwal, Lynn Macdonald, Andrew Murphy, Frank Kuhnert

Short tandem repeat profiling via next generation sequencing for cell line authentication

Yi-Hsien Chen, Jon P. Connelly, Colin Florian, Xiaoxia Cui, Shondra M. Pruett-Miller

Using Drosophila to model a variant of unknown significance in the human cardiogenic gene Nkx2.5

TyAnna L. Lovato, Brenna Blotz, Cayleen Bileckyj, Christopher A. Johnston, Richard M. Cripps

More accepted manuscripts

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Issues

Cover Image

In This Issue

Research Highlights

Editorial

A Model For Life

Clinical Puzzle

Special Article

Commentaries

Perspectives

Podcast

Research Articles

Research Report

Email alerts

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