Issues
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Cover image
Cover Image
Cover: Stylised confocal image of a zebrafish retina 5 days after fertilisation. Müller glia extend processes throughout the retina, providing structural and non-cell-autonomous support for retinal neurons. The zebrafish protein harmonin (red) localises to Müller cell bodies and processes. Müller cells are also labelled in green in this image, appearing yellow/orange when merged with the red. Defects or deletions in harmonin are causative of Usher syndrome type 1C (USH1C), a severe form of hereditary deaf-blindness. Zebrafish models of human USH1C implicate Müller cells as contributors to visual function and photoreceptor survival. See article by Phillips et al. on page 786. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
A NOD to zebrafish models of inflammatory bowel disease pathogenesis
Summary and comment on a Research Report in this issue of Disease Models & Mechanisms entitled ‘The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish’ (Oehlers et al., 2011).
Pathological looping in the synucleinopathies: investigating the link between Parkinson’s disease and Gaucher disease
Summary and comment on a recent Cell paper entitled ‘Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies’ (Mazzulli et al., 2011).
A Model For Life
Mouse genetics for studying mechanisms of deafness and more: an interview with Karen Steel
Karen Steel has dedicated her career to unravelling the many mechanisms underlying deafness using mouse genetics. In this interview, she explains how this area has engaged her attention since the first day she began her PhD, and discusses the power of mouse genetics programmes for advancing all areas of biomedical research.
Book Review
Clinical Puzzle
At A Glance
Special Article
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
Commentary
Perspective
Podcast
Research Articles
Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function
Research Reports
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
