Issues
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Cover image
Cover Image
Cover: Stylised confocal image of a zebrafish retina 5 days after fertilisation. Müller glia extend processes throughout the retina, providing structural and non-cell-autonomous support for retinal neurons. The zebrafish protein harmonin (red) localises to Müller cell bodies and processes. Müller cells are also labelled in green in this image, appearing yellow/orange when merged with the red. Defects or deletions in harmonin are causative of Usher syndrome type 1C (USH1C), a severe form of hereditary deaf-blindness. Zebrafish models of human USH1C implicate Müller cells as contributors to visual function and photoreceptor survival. See article by Phillips et al. on page 786. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Journal Club
A NOD to zebrafish models of inflammatory bowel disease pathogenesis
Summary and comment on a Research Report in this issue of Disease Models & Mechanisms entitled ‘The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish’ (Oehlers et al., 2011).
Pathological looping in the synucleinopathies: investigating the link between Parkinson’s disease and Gaucher disease
Summary and comment on a recent Cell paper entitled ‘Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies’ (Mazzulli et al., 2011).
A Model For Life
Mouse genetics for studying mechanisms of deafness and more: an interview with Karen Steel
Karen Steel has dedicated her career to unravelling the many mechanisms underlying deafness using mouse genetics. In this interview, she explains how this area has engaged her attention since the first day she began her PhD, and discusses the power of mouse genetics programmes for advancing all areas of biomedical research.
Book Review
Clinical Puzzle
At A Glance
Special Article
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
Commentary
Perspective
Podcast
Research Articles
Harmonin (Ush1c) is required in zebrafish Müller glial cells for photoreceptor synaptic development and function
Research Reports
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
A new call for papers is underway
Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
NOTCH signalling – a core regulator of bile duct disease?
In this Review, Anabel Martinez Lyons and Luke Boulter explore the concepts of NOTCH signalling reactivation in the biliary epithelium and how it is a reiterative and essential response to bile duct damage. Read the full Review Article here.
