Issues
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Cover image
Cover Image
Cover: The tobacco hawkmoth (Manduca sexta) provides a complementary bioassay for identifying compounds that might reduce the effects of dysregulated Ca2+ homeostasis associated with Alzheimer's disease (AD). This bioassay was combined with three others (a neuroblastoma model of amyloid toxicity, a Drosophila model and a transgenic mouse model of AD) to test whether dihydropyridines are protective against the neurotoxic effects of β-amyloid. See article by Copenhaver et al. on page 634. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
A Model For Life
From immunological tolerance to stem cell therapy and back: an interview with Irving Weissman
Irv Weissman has pursued many areas of biomedical research throughout his prolific career as a medical doctor and researcher. In this interview, he recalls his early years studying immunology in mice, and discusses the more recent challenges he has faced when attempting to develop stem-cell-based therapies with industry.
Clinical Puzzle
Primers
At A Glance
Commentary
Perspective
Podcast
Research Articles
A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug
Resource Article
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis
Research Report
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
