Issues
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Cover image
Cover Image
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Cover: The tobacco hawkmoth (Manduca sexta) provides a complementary bioassay for identifying compounds that might reduce the effects of dysregulated Ca2+ homeostasis associated with Alzheimer's disease (AD). This bioassay was combined with three others (a neuroblastoma model of amyloid toxicity, a Drosophila model and a transgenic mouse model of AD) to test whether dihydropyridines are protective against the neurotoxic effects of β-amyloid. See article by Copenhaver et al. on page 634.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
A Model For Life
From immunological tolerance to stem cell therapy and back: an interview with Irving Weissman
Irv Weissman has pursued many areas of biomedical research throughout his prolific career as a medical doctor and researcher. In this interview, he recalls his early years studying immunology in mice, and discusses the more recent challenges he has faced when attempting to develop stem-cell-based therapies with industry.
Clinical Puzzle
Primers
At A Glance
Commentary
Perspective
Podcast
Research Articles
A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug
Resource Article
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis
Research Report
Special Issue: The RAS Pathway
Our latest special issue is now complete. It showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems.
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Propose a new Workshop
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country. .
A focus on Drosophila
In a series of front section articles, DMM is highlighting the versatility, breadth, and scope of Drosophila research in human disease modelling and translational medicine.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 6 June 2022. Find out more and hear from past recipients about their experience of the grant.
