Issues
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Cover Image
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Cover: The tobacco hawkmoth (Manduca sexta) provides a complementary bioassay for identifying compounds that might reduce the effects of dysregulated Ca2+ homeostasis associated with Alzheimer's disease (AD). This bioassay was combined with three others (a neuroblastoma model of amyloid toxicity, a Drosophila model and a transgenic mouse model of AD) to test whether dihydropyridines are protective against the neurotoxic effects of β-amyloid. See article by Copenhaver et al. on page 634.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
A Model For Life
From immunological tolerance to stem cell therapy and back: an interview with Irving Weissman
Irv Weissman has pursued many areas of biomedical research throughout his prolific career as a medical doctor and researcher. In this interview, he recalls his early years studying immunology in mice, and discusses the more recent challenges he has faced when attempting to develop stem-cell-based therapies with industry.
Clinical Puzzle
Primers
At A Glance
Commentary
Perspective
Podcast
Research Articles
A translational continuum of model systems for evaluating treatment strategies in Alzheimer’s disease: isradipine as a candidate drug
Resource Article
A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis
Research Report
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Grants awarded by The Company of Biologists help scientists travel, attend events and host sustainable activities. Make a note of the upcoming application deadlines and find out more about the grants on offer:
DMM Conference Travel Grants
17 May 2021
Sustainable Conferencing Grants
17 May 2021
Travelling Fellowships
31 May 2021
Scientific Meeting Grants
4 June 2021
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.
