Issues
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Cover image
Cover Image
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Cover: A 17.5-day-old chimeric mouse embryo that was obtained by microinjecting three different mouse embryonic stem (ES) cell lines, which individually express cyan, green or red fluorescent proteins under control of the ROSA26 locus, into 3-day-old blastocysts obtained from the natural matings of C57Bl/6 mice. The cyan, green and red fluorescence in this high-degree polychromatic embryo reflect the specific developmental contributions of the injected ES cells. See article by Chen et al. on page 537.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Editorial
Journal Club
Parkin’ control: regulation of PGC-1α through PARIS in Parkinson’s disease
Summary and comment on a recent Cell paper entitled ‘PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease’ (Shin et al., 2011).
A Model For Life
Innovating immunology: an interview with Ruslan Medzhitov
Ruslan Medzhitov was inspired to become a researcher in immunology on reading a 1989 paper written by Charles Janeway that outlined a new theory for immune system activation. Just a few years later, having achieved a postdoc position in Janeway’s lab, he carried out the experiments that confirmed the theory, re-igniting interest in the field of innate immunity and launching his own career. Here, he discusses this early discovery and explains what he considers the three most important questions facing immunologists today.
Primers
Commentary
Perspective
Podcast
Research Articles
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
Resource Article
Research Report
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Call for new preLighters
preLights is the preprint highlighting community supported by The Company of Biologists. At the heart of preLights are our preLighters: early-career researchers who select and write about interesting new preprints for the research community. We are currently looking for new preLighters to join our team. Find out more and apply here.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
