Issues
-
Cover image
Cover Image
![issue cover]()
Cover: A 17.5-day-old chimeric mouse embryo that was obtained by microinjecting three different mouse embryonic stem (ES) cell lines, which individually express cyan, green or red fluorescent proteins under control of the ROSA26 locus, into 3-day-old blastocysts obtained from the natural matings of C57Bl/6 mice. The cyan, green and red fluorescence in this high-degree polychromatic embryo reflect the specific developmental contributions of the injected ES cells. See article by Chen et al. on page 537.Close Modal - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Editorial
Journal Club
Parkin’ control: regulation of PGC-1α through PARIS in Parkinson’s disease
Summary and comment on a recent Cell paper entitled ‘PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease’ (Shin et al., 2011).
A Model For Life
Innovating immunology: an interview with Ruslan Medzhitov
Ruslan Medzhitov was inspired to become a researcher in immunology on reading a 1989 paper written by Charles Janeway that outlined a new theory for immune system activation. Just a few years later, having achieved a postdoc position in Janeway’s lab, he carried out the experiments that confirmed the theory, re-igniting interest in the field of innate immunity and launching his own career. Here, he discusses this early discovery and explains what he considers the three most important questions facing immunologists today.
Primers
Commentary
Perspective
Podcast
Research Articles
Zebrafish embryo screen for mycobacterial genes involved in the initiation of granuloma formation reveals a newly identified ESX-1 component
Resource Article
Research Report
Development/DMM Virtual Meeting 2021
Registration is now open to apply to attend our Development/DMM Virtual Meeting 2021: Developmental Disorders: From Mechanism to Treatment, 14-17 September 2021.
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic.
Happy birthday FocalPlane
On 1 July, FocalPlane celebrated its first birthday!
Look back over the community site's successful first year and join the celebrations as FocalPlane launches a new image competition to feature on the cover of Journal of Cell Science.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 28 August. Find out more and hear from past recipients about their experience of the grant.
Special issue: The RAS pathway
Our next special issue showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems. Stay up-to-date with the latest articles as the issue builds.
