Issues
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Cover image
Cover Image
Cover: Ventral view of a cranial bone preparation of an E18.5 mouse embryo stained with Alizarin Red and Alcian Blue for bone and cartilage, respectively. Mice lacking the SHH pathway regulator Cdo display mild rostroventral midline patterning defects as part of the holoprosencephaly (HPE) spectrum. Mice lacking the Cdo-related factor Boc do not have midline defects but genetic removal of Boc dose-dependently enhances HPE phenotypes associated with mutation of Cdo. The preparation is from a Cdo−/−;Boc−/− mutant and shows such HPE-associated defects as fused premaxillary bones, dysmorphic maxillary bones and an underdeveloped basisphenoid bone. See article by Zhang et al. on page 368. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Editorials
Journal Club
InACTIVatINg cancer cachexia
Summary of and comment on a recent Cell paper entitled ‘Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival’ (Zhou et al., 2010).
Model for Life
Translating science in more ways than one: an interview with Frances Balkwill
Professor Frances Balkwill of Barts Cancer Institute, Queen Mary, University of London, is driven by two passions: translating basic cancer research into new patient therapies and encouraging science literacy in children through a range of communication-based activities. In this interview, she discusses current challenges in translational cancer research and how the two arms of her career inspire one another.
Clinical Puzzles
Primer
At a Glance
Commentary
Perspective
Podcast
Research Articles
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
