Issues

Cover: Ventral view of a cranial bone preparation of an E18.5 mouse embryo stained with Alizarin Red and Alcian Blue for bone and cartilage, respectively. Mice lacking the SHH pathway regulator Cdo display mild rostroventral midline patterning defects as part of the holoprosencephaly (HPE) spectrum. Mice lacking the Cdo-related factor Boc do not have midline defects but genetic removal of Boc dose-dependently enhances HPE phenotypes associated with mutation of Cdo. The preparation is from a Cdo^−/−;Boc^−/− mutant and shows such HPE-associated defects as fused premaxillary bones, dysmorphic maxillary bones and an underdeveloped basisphenoid bone. See article by Zhang et al. on page 368.