Issues
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Cover image
Cover Image
Cover: Ventral view of a cranial bone preparation of an E18.5 mouse embryo stained with Alizarin Red and Alcian Blue for bone and cartilage, respectively. Mice lacking the SHH pathway regulator Cdo display mild rostroventral midline patterning defects as part of the holoprosencephaly (HPE) spectrum. Mice lacking the Cdo-related factor Boc do not have midline defects but genetic removal of Boc dose-dependently enhances HPE phenotypes associated with mutation of Cdo. The preparation is from a Cdo−/−;Boc−/− mutant and shows such HPE-associated defects as fused premaxillary bones, dysmorphic maxillary bones and an underdeveloped basisphenoid bone. See article by Zhang et al. on page 368. - PDF Icon PDF LinkTable of contents
In This Issue
Research Highlights
Editorials
Journal Club
InACTIVatINg cancer cachexia
Summary of and comment on a recent Cell paper entitled ‘Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival’ (Zhou et al., 2010).
Model for Life
Translating science in more ways than one: an interview with Frances Balkwill
Professor Frances Balkwill of Barts Cancer Institute, Queen Mary, University of London, is driven by two passions: translating basic cancer research into new patient therapies and encouraging science literacy in children through a range of communication-based activities. In this interview, she discusses current challenges in translational cancer research and how the two arms of her career inspire one another.
Clinical Puzzles
Primer
At a Glance
Commentary
Perspective
Podcast
Research Articles
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
