Issues
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Cover image
Cover Image
Cover: Depolarisation of transmembrane potential in a select group of 'instructor cells' triggers a profoundly hyperpigmented phenotype in Xenopus laevis tadpoles (shown in the figure) owing to a neoplastic-like conversion of melanocytes. When activated by a serotonergic signal from the depolarised instructor cells, melanocytes overproliferate, acquire a highly dendritic morphology, and aggressively colonise organs and blood vessels throughout the animal. See article by Blackiston et al. on page 67. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
EDITORIAL
JOURNAL CLUB
A MODEL FOR LIFE
At the leading edge of cancer research: an interview with Joan Brugge
Joan Brugge has been an innovator in cancer research since the beginning of her career, when she isolated the viral and cellular forms of the Src protein as a postdoctoral fellow at the University of Colorado. In this interview, she describes the exciting sequence of events that opened up the field during this time, and discusses why a career in cancer research is still such an inspiring path to follow today.
PRIMER
PERSPECTIVE
RESEARCH ARTICLE
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress
RESEARCH REPORT
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
