Issues
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Cover image
Cover Image
Cover: Depolarisation of transmembrane potential in a select group of 'instructor cells' triggers a profoundly hyperpigmented phenotype in Xenopus laevis tadpoles (shown in the figure) owing to a neoplastic-like conversion of melanocytes. When activated by a serotonergic signal from the depolarised instructor cells, melanocytes overproliferate, acquire a highly dendritic morphology, and aggressively colonise organs and blood vessels throughout the animal. See article by Blackiston et al. on page 67. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
EDITORIAL
JOURNAL CLUB
A MODEL FOR LIFE
At the leading edge of cancer research: an interview with Joan Brugge
Joan Brugge has been an innovator in cancer research since the beginning of her career, when she isolated the viral and cellular forms of the Src protein as a postdoctoral fellow at the University of Colorado. In this interview, she describes the exciting sequence of events that opened up the field during this time, and discusses why a career in cancer research is still such an inspiring path to follow today.
PRIMER
PERSPECTIVE
RESEARCH ARTICLE
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome
PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress
RESEARCH REPORT
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru
Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
