Issues
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Cover: Stylised reflection of fluorescently labelled soft-tissue sarcoma in a mouse. Primary soft-tissue sarcomas are generated with a spatially and temporally controlled model in genetically modified mice. Through adenovirus-mediated delivery of Cre recombinase, activation of oncogenic Kras and deletion of p53 result in tumours that are useful for therapeutic studies. The image displays a tumour-activatable dye (red) within the tumour architecture (plasma membrane, green). Nuclei are stained with DAPI (blue). See Perspective by Dodd et al. on page 557.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
COMMUNITY NEWS
A MODEL FOR LIFE
The extracellular matrix and disease: an interview with Zena Werb
Zena Werb’s pioneering efforts brought recognition to the idea that the extracellular matrix has a profound influence in determining cell fate. Here, she discusses how a ‘rocky’ start in geophysics led her to a career that is changing the way we think about cancer.
PRIMER
SPECIAL ARTICLE
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation
RESOURCE ARTICLE
Development/DMM Virtual Meeting 2021
Registration is now open to apply to attend our Development/DMM Virtual Meeting 2021: Developmental Disorders: From Mechanism to Treatment, 14-17 September 2021.
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 28 August. Find out more and hear from past recipients about their experience of the grant.
Special issue: The RAS pathway
Our next special issue showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems. Stay up-to-date with the latest articles as the issue builds.
