Issues
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Cover image
Cover Image
Cover: Stylised reflection of fluorescently labelled soft-tissue sarcoma in a mouse. Primary soft-tissue sarcomas are generated with a spatially and temporally controlled model in genetically modified mice. Through adenovirus-mediated delivery of Cre recombinase, activation of oncogenic Kras and deletion of p53 result in tumours that are useful for therapeutic studies. The image displays a tumour-activatable dye (red) within the tumour architecture (plasma membrane, green). Nuclei are stained with DAPI (blue). See Perspective by Dodd et al. on page 557. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
COMMUNITY NEWS
A MODEL FOR LIFE
The extracellular matrix and disease: an interview with Zena Werb
Zena Werb’s pioneering efforts brought recognition to the idea that the extracellular matrix has a profound influence in determining cell fate. Here, she discusses how a ‘rocky’ start in geophysics led her to a career that is changing the way we think about cancer.
PRIMER
SPECIAL ARTICLE
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation
RESOURCE ARTICLE
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
