Issues
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Cover: Stylised reflection of fluorescently labelled soft-tissue sarcoma in a mouse. Primary soft-tissue sarcomas are generated with a spatially and temporally controlled model in genetically modified mice. Through adenovirus-mediated delivery of Cre recombinase, activation of oncogenic Kras and deletion of p53 result in tumours that are useful for therapeutic studies. The image displays a tumour-activatable dye (red) within the tumour architecture (plasma membrane, green). Nuclei are stained with DAPI (blue). See Perspective by Dodd et al. on page 557.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
COMMUNITY NEWS
A MODEL FOR LIFE
The extracellular matrix and disease: an interview with Zena Werb
Zena Werb’s pioneering efforts brought recognition to the idea that the extracellular matrix has a profound influence in determining cell fate. Here, she discusses how a ‘rocky’ start in geophysics led her to a career that is changing the way we think about cancer.
PRIMER
SPECIAL ARTICLE
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation
RESOURCE ARTICLE
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
