Issues
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Cover image
Cover Image
Confocal projection of a vibratome cross-section through the head of a 7 days post-fertilization zebrafish larva that is mutant in the von Hippel-Lindau (vhl) tumor suppressor gene. Blood vessels are labeled in green. TG(kdr-like:egfp) vhl mutants develop pronounced neovascularization of the brain and eyes. Fluorescent angiography with a 2,000,000 molecular weight rhodamine-dextran conjugate (red), which is normally too large to pass through the vessel wall, reveals severe vascular leakage in vhl mutants at 20-25 hours post-injection. In the vhl−/− eye this leads to the formation of macular edema (red patches), similar to human angiogenic retinopathies. See research article by van Rooijen et al. on page 343. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Funding scientific discovery: an interview with Sir Mark Walport
Sir Mark Walport is Director of the Wellcome Trust, one of the world’s largest funders of scientific research. Here he talks about the qualities of a successful scientist and how informatics might advance the future of medicine.
CLINICAL PUZZLE
PRIMER
SPECIAL ARTICLE
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Stromal regulation of vessel stability by MMP14 and TGFβ
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
