Issues
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Cover image
Cover Image
Confocal projection of a vibratome cross-section through the head of a 7 days post-fertilization zebrafish larva that is mutant in the von Hippel-Lindau (vhl) tumor suppressor gene. Blood vessels are labeled in green. TG(kdr-like:egfp) vhl mutants develop pronounced neovascularization of the brain and eyes. Fluorescent angiography with a 2,000,000 molecular weight rhodamine-dextran conjugate (red), which is normally too large to pass through the vessel wall, reveals severe vascular leakage in vhl mutants at 20-25 hours post-injection. In the vhl−/− eye this leads to the formation of macular edema (red patches), similar to human angiogenic retinopathies. See research article by van Rooijen et al. on page 343. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Funding scientific discovery: an interview with Sir Mark Walport
Sir Mark Walport is Director of the Wellcome Trust, one of the world’s largest funders of scientific research. Here he talks about the qualities of a successful scientist and how informatics might advance the future of medicine.
CLINICAL PUZZLE
PRIMER
SPECIAL ARTICLE
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Stromal regulation of vessel stability by MMP14 and TGFβ
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru
Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
