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A pseudocolored three-dimensional (3D) reconstruction of the outer hair cells from a TectaC1509G/+ mouse cochlea labeled with the calcium indicator dye OGB-1AM. In wild-type mice, the tectorial membrane covers all three outer hair cell rows, whereas the tectorial membrane in TectaC1509G/+ mice only reaches the first row of cells. In TectaC1509G/+ mice, the malformed tectorial membrane produced increased calcium within the first row of outer hair cells compared with cells in the second and third rows. See research article by Xia et al. on page 209.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Embracing new ideas: an interview with Maria Leptin
Maria Leptin works simultaneously in the independent fields of immunology and development. She is the new director of the European Molecular Biology Organization (EMBO) and runs a laboratory in Heidelberg, as well as one in Cologne. Here, she describes how she moved between fields and some of the mechanisms that she believes foster creative science.
CLINICAL PUZZLE
PRIMER
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models
RESEARCH REPORT
Special Issue: The RAS Pathway
Our latest special issue is now complete. It showcases RAS-driven mechanisms of disease progression, and highlights approaches to treat and modify the disease course in model systems.
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. Submission deadline: 4 July 2022.
Propose a new Workshop
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country. .
A focus on Drosophila
In a series of front section articles, DMM is highlighting the versatility, breadth, and scope of Drosophila research in human disease modelling and translational medicine.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 6 June 2022. Find out more and hear from past recipients about their experience of the grant.
