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A pseudocolored three-dimensional (3D) reconstruction of the outer hair cells from a TectaC1509G/+ mouse cochlea labeled with the calcium indicator dye OGB-1AM. In wild-type mice, the tectorial membrane covers all three outer hair cell rows, whereas the tectorial membrane in TectaC1509G/+ mice only reaches the first row of cells. In TectaC1509G/+ mice, the malformed tectorial membrane produced increased calcium within the first row of outer hair cells compared with cells in the second and third rows. See research article by Xia et al. on page 209.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Embracing new ideas: an interview with Maria Leptin
Maria Leptin works simultaneously in the independent fields of immunology and development. She is the new director of the European Molecular Biology Organization (EMBO) and runs a laboratory in Heidelberg, as well as one in Cologne. Here, she describes how she moved between fields and some of the mechanisms that she believes foster creative science.
CLINICAL PUZZLE
PRIMER
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models
RESEARCH REPORT
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Grants awarded by The Company of Biologists help scientists travel, attend events and host sustainable activities. Make a note of the upcoming application deadlines and find out more about the grants on offer:
DMM Conference Travel Grants
17 May 2021
Sustainable Conferencing Grants
17 May 2021
Travelling Fellowships
31 May 2021
Scientific Meeting Grants
4 June 2021
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.
