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Pancreatic tumors grown in the absence of host-derived SPARC display reduced hypoxia relative to controls. Mice bearing orthotopic pancreatic PAN02 tumors were injected intravenously with a hypoxia marker (Hypoxyprobe-1). Hypoxia within tumors was visualized using an antibody, FITC-conjugated mouse anti-pimonidazole, directed against an adduct that forms when Hypoxyprobe-1 enters hypoxic tissue. The image displays hypoxia (green) near the vasculature (red) stained with a rat anti-mouse endothelial cell antibody (Meca-32). Nuclei are stained with DAPI (blue). See research article by Arnold et al. on page 57.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
The accidental biologist: an interview with Jim Smith
Jim Smith has made fundamental contributions to our understanding of early embryonic development. Here, in conversation with DMM Consulting Editor Kathy Weston, he discusses his stutter, how he became interested in developmental biology, and his role in helping establish what will be the UK’s biggest multidisciplinary research laboratory, the UK Centre for Medical Research and Innovation (UKCMRI).
FEATURE
Primates as a model for research
Despite the political, ethical and financial complexities, there are some human diseases that researchers feel can only be understood by working with non-human primates. Nicole Garbarini investigates.
BOOK & ART REVIEW
CLINICAL PUZZLE
PRIMER
COMMENTARY
RESEARCH ARTICLE
RESEARCH REPORT
Call for papers: Moving Heart Failure to Heart Success
Disease Models & Mechanisms is pleased to welcome submissions for consideration for an upcoming special issue, Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy. The deadline for submitting articles to the special issue has been extended to 1 August 2022.
Modelling interactions at the blood–brain barrier
In their Review, Yvonne Adams and Anja Ramstedt Jensen review the available in vitro models to investigate the impact of adhesion of Plasmodium falciparum-infected red blood cells on the blood–brain barrier, a process associated with cerebral malaria.
Focus on Genetic Variance in Human Disease
New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. DMM’s new Subject Focus highlights this evolving area of research.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 1 September 2022. Find out more and hear from past recipients about their experience of the grant.
