Issues
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Cover image
Cover Image
Pancreatic tumors grown in the absence of host-derived SPARC display reduced hypoxia relative to controls. Mice bearing orthotopic pancreatic PAN02 tumors were injected intravenously with a hypoxia marker (Hypoxyprobe-1). Hypoxia within tumors was visualized using an antibody, FITC-conjugated mouse anti-pimonidazole, directed against an adduct that forms when Hypoxyprobe-1 enters hypoxic tissue. The image displays hypoxia (green) near the vasculature (red) stained with a rat anti-mouse endothelial cell antibody (Meca-32). Nuclei are stained with DAPI (blue). See research article by Arnold et al. on page 57. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
The accidental biologist: an interview with Jim Smith
Jim Smith has made fundamental contributions to our understanding of early embryonic development. Here, in conversation with DMM Consulting Editor Kathy Weston, he discusses his stutter, how he became interested in developmental biology, and his role in helping establish what will be the UK’s biggest multidisciplinary research laboratory, the UK Centre for Medical Research and Innovation (UKCMRI).
FEATURE
Primates as a model for research
Despite the political, ethical and financial complexities, there are some human diseases that researchers feel can only be understood by working with non-human primates. Nicole Garbarini investigates.
BOOK & ART REVIEW
CLINICAL PUZZLE
PRIMER
COMMENTARY
RESEARCH ARTICLE
RESEARCH REPORT
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
