Issues
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Cover image
Cover Image
Mitochondria and Legionella infections in the social amoeba. The image shows multicellular fruiting bodies (gold) of the social amoeba or cellular slime mould, Dictyostelium discoideum. The fruiting bodies are 1-2 mm high. The rough outline of a single amoeba (magenta) encloses mitochondria (green, GFP fluorescence) and four Legionella pneumophila (red, DsRed fluorescence) that have infected the cell. The diameter of the cell is approximately 12 μm. In this issue of DMM, Francione et al. report that chronic AMPK signaling causes mitochondrially diseased Dictyostelium cells to support intracellular Legionella proliferation better than wild-type cells. Image by P. R. Fisher and P. E. Taylor. See research article on page 479. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Taking translational research to heart: an interview with Sir Magdi Yacoub
Sir Magdi Yacoub is a founding editor of DMM, whose work as a cardiac surgeon and researcher has devised new operations for congenital and acquired heart disease, and has advanced heart and heart-lung transplantation techniques. He and his collaborators have studied the sophisticated functions of living heart valves and are using stem cells to produce a tissue-engineered valve that can reproduce their functions. Here, he discusses with fellow DMM founding editor Nadia Rosenthal, how his career evolved and why he hopes research will put heart surgeons like himself out of business.
CLINICAL PUZZLE
PRIMER
PERSPECTIVE
RESEARCH ARTICLE
RESOURCE ARTICLE
ERRATUM
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, speakers will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that investigate the genetic and biological mechanisms of heart failure and identify potential therapeutic strategies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share guidance about how new technologies and different conference formats work in practice.
