Issues
-
Cover image
Cover Image
Mice with a conditional deletion of the Pten gene in neurons recapitulate many features of cortical dysplasia, a common cause of childhood epilepsy. These include spontaneous seizures, cell hypertrophy and elevated activity of the PI3K-Akt-mTOR signaling pathway. In the foreground are EEG traces showing different types of epileptiform activity in the mutant mice (bottom four traces) compared with wild-type mice (top trace). In the background is a section of the Pten mutant mouse cerebral cortex labeled with antibodies against Pten (green) and phospho-S6 (red). This image reveals the excessive activation of the PI3K-Akt-mTOR pathway in enlarged, Pten-negative neurons. See research article by Ljungberg et al. on page 389. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Anti-angiogenic drugs to treat human disease: an interview with Napoleone Ferrara
Napoleone Ferrara identified vascular endothelial growth factor (VEGF) as a major regulator of blood vessel development. The antibodies that he and his colleagues created to block VEGF action also block cancer growth. Here, he discusses the work that led to the development of the anti-cancer drug Avastin (bevacizumab), and discusses the role of basic science in clinical medicine.
FEATURE
Researchers focus on inflammation at the Istituto Clinico Humanitas
With international recognition as a premier medical institute, the Istituto Clinico Humanitas pulls disease questions from their patients in the clinic into their preclinical work in the lab investigates.
CLINICAL PUZZLE
PRIMER
COMMENTARY
PERSPECTIVE
RESEARCH ARTICLE
An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy
RESEARCH REPORT
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The deadline for abstract submission and early-bird registration is 17 January 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine
In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
