Issues
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A girl with Wolf-Hirschhorn syndrome (WHS) is holding a mouse, reflecting the significant biological relationship between the two species whereby mice can serve as a model system to study human disease. Mice that are homozygous for a null allele of the fibroblast growth factor receptor-like 1 (Fgfrl1) gene recapitulate multiple aspects of WHS, including skeletal malformations and cardiac valve defects. See research article by Catela et al. on page 283.Close Modal - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
JOURNAL CLUB
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
Using zebrafish to understand the genome: an interview with Nancy Hopkins
Nancy Hopkins is famous for pushing the envelope: both in her pursuit to understand cancer genetics and in exposing professional disparities between men and women. Here, she discusses influential moments that have defined her career path, and her concerns for the future.
CLINICAL PUZZLE
PRIMER
AT A GLANCE
PERSPECTIVE
RESEARCH ARTICLE
RESEARCH REPORT
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
A multi-omics approach provides insight into DUX4-induced stresses
Facioscapulohumeral muscular dystrophy is caused by misexpression of the DUX4 transcription factor. Christopher Brennan et al. take a multi-omics approach to show that MAP kinase pathways are activated in response to DUX4 expression and that this contributes to DUX4-mediated cell death.
COVID-19’s next top model
Jeong and colleagues infect K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2 to obtain comprehensive insights into COVID-19 pathogenicity in these preclinical models. This article has been highlighted as our Editor’s Choice.
Apply for a DMM Conference Travel Grant
Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.
The future of model organism research
We recently published a series of articles that consider how researchers can best leverage model organisms to improve our understanding of human health and disease. You can find a summary with links to the individual articles here.
