Issues
-
Cover image
Cover Image
Zebrafish homozygous for the H-RASV12 transgene develop traits of Costello syndrome, including scoliosis and heart defects. The model helps to elucidate how germline expression of the oncogene causes a developmental degenerative phenotype. In the background, adult heart proliferating cells are marked by BrdU staining (green). See research article by Santoriello et al. on page 56. - PDF Icon PDF LinkTable of contents
IN THIS ISSUE
RESEARCH HIGHLIGHT
EDITORIAL
COMMUNITY NEWS
A MODEL FOR LIFE
The birth of cloning: an interview with John Gurdon
Sir John Gurdon used nuclear transplantation and cloning to show that the nucleus of a differentiated somatic cell retains the totipotency necessary to form a whole organism. Here, he discusses model organisms, the future implications for his early work on medicine and his thoughts about scientific publishing.
BOOK & ART REVIEW
CLINICAL PUZZLE
PRIMER
PERSPECTIVE
RESEARCH ARTICLE
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy
Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue
DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Crossroads in Virology
Our October Editorial written by Sumana Sanyal emphasises the urgency of a concerted effort in understanding virus–host interactions to inform the development of therapeutics and vaccines, helping to predict disease outcomes. Read the full Editorial here.
A Model for Life - an interview with Professor Kiran Musunuru
Read our new A Model for Life interview with Kiran Musunuru. Prof Musunuru investigates the mechanisms of disease in model systems, with the ultimate goal of developing innovative gene editing therapies.
Sustainable Conferencing Initiative
Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
