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Cover image
Cover Image
Cover: A confocal microscopy image of optically cleared fetal mouse kidney cortex, stained for endomucin (red) to highlight the microvasculature, with tissue architecture revealed by autofluorescence (white). A normal kidney (bottom right) is contrasted with a Pkd1 mutant kidney (top left), in which tubular dilation and microvascular remodelling are already evident at this prenatal stage. This mouse model of autosomal dominant polycystic kidney disease (ADPKD) demonstrates similar molecular alterations, as well as structural and functional perturbations, as those in ADPKD patients. See article by Jafree et al. (dmm052024). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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A MODEL FOR LIFE
PERSPECTIVES
Expanding the neuroimmune research toolkit with in vivo brain organoid technologies
Summary: This Perspective examines diverse neuroimmune research platforms, highlighting recent advances in in vivo xenotransplantation alongside alternative techniques, discussing their complementary benefits, limitations and potential for advancing the field.
The physiological functions of ascorbate in the development of cancer
Summary: This Perspective argues that the physiological functions of ascorbate in the development of cancer must be defined using ascorbate depletion experiments. This will inform the design of clinical trials of ascorbate in cancer prevention or treatment.
EDITOR'S CHOICE
RESEARCH ARTICLES
Oncogenic signaling in the Drosophila prostate-like accessory gland activates a pro-tumorigenic program in the absence of proliferation
Summary: The Drosophila prostate-like accessory gland is a postmitotic and polyploid tissue. Here, we show similarities between the oncogenic activity in the Drosophila accessory gland and in polyploid prostate cancer cells.
Glucose uptake in pigment glia suppresses Tau-induced inflammation and photoreceptor degeneration
Summary: Glucose uptake into pigment glia cells suppresses inflammatory responses and photoreceptor degeneration in the Drosophila model of tauopathy.
Modeling ANKRD26 5′-UTR mutation-related thrombocytopenia
Summary: A small deletion mutation in the 5'-UTR of ankrd26 results in spontaneous thrombocytopenia in zebrafish, recapitulating the phenotype in patients with thrombocytopenia 2.
Patient-specific mutation of contact site protein Tomm70 causes neurodegeneration
Summary: A mutation in the mitochondrial receptor protein Tomm70 disrupts neuronal and molecular processes in zebrafish, providing critical insights into the neurodegenerative mechanisms underlying hereditary spastic paraplegia.
Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model
A distinct subpopulation of aberrant microvasculature was identified in human polycystic kidneys. Similar abnormalities in mice, together with structural and functional microvascular changes, were found to precede excretory kidney failure.
Anatomical and functional studies of vestibular neuroepithelia from patients with Ménière's disease
Summary: Electrophysiological recordings of surviving vestibular hair cells from Ménière's disease patients show normal voltage-activated currents, while immunofluorescent labelling of these cells shows disorganised neuroepithelia.
Mutations in the bone morphogenetic protein signaling pathway sensitize zebrafish and humans to ethanol-induced jaw malformations
Summary: We apply a unique combination of zebrafish-based approaches, and human genetics and facial dysmorphology analyses to resolve the cellular mechanisms that are driven by the ethanol-sensitive Bmp pathway.
FIRST PERSON
CORRECTION
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery
We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review
Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
Propose a new Workshop for 2027
We are currently seeking proposals for Workshops to be held in 2027. As one of the scientific organisers of a The Company of Biologists Workshop, your involvement will be focused on interdisciplinary, cutting-edge science and promoting new partnerships and collaborations. We focus on the logistics. Are you thinking about proposing a topic for one of our Workshops? Apply by Friday 30 May 2025.
