Issues
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Cover image
Cover Image
Cover: The axolotl (Ambystoma mexicanum) is an aquatic three-gilled amphibian and one of the most useful animal models in regenerative biology, given their ability to fully reconstruct a number of body structures, including limbs and the lower jaw. Within 90 days, the axolotl can regenerate its mandible through mechanisms that reduce the size of the defect and by exhibiting similar regenerative stages and transcriptomic profiles to those of the regenerating limb. See article by Kramer et al. (dmm050743). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Supporting the evolution of infectious disease research
Summary: In anticipation of our Special Issue, ‘Infectious Disease: Evolution, Mechanism and Global Health’, we celebrate recent advances made in this field and the success of our Infectious Disease Journal Meeting.
REVIEWS
Preclinical evaluation of targeted therapies for central nervous system metastases
Summary: This Review discusses the preclinical evidence for targeted therapies in treating central nervous system metastases and how these data correlate with clinical outcomes.
Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment
Summary: This Review discusses how the tumor microenvironment regulates lipid metabolism in cancers and how lipid metabolism in cancers reciprocally affects tumor metabolism and biology.
EDITOR'S CHOICE
RESEARCH ARTICLES
Activation of the heat shock response as a therapeutic strategy for tau toxicity
Summary: Activation of the heat shock response both genetically and pharmacologically was found to ameliorate tau toxicity in C. elegans.
A Drosophila model for mechanistic investigation of tau protein spread
Summary: Our bipartite transgenic Drosophila model allows the analysis of tau protein spread to the brain and identifies the underlying mechanisms of tau trafficking in neurodegenerative diseases.
Compromised COPII vesicle trafficking leads to glycogenic hepatopathy
Summary: The sec31a-mutant zebrafish model provides insights into the processes of glycogenic hepatopathy associated with vesicle trafficking impairments and reveals the pathological interplay between the thyroid and liver.
Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb
Editor's choice: Axolotls can regenerate mandibles using mechanisms that reduce the defect size and by exhibiting similar regenerative stages and transcriptomic profiles to those of the regenerating limb.
Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model
Summary: Analysis of the developing bone in Ts65Dn Down syndrome model mice reveals timepoints during development when trisomic Dyrk1a is linked to appendicular skeletal abnormalities, despite Dyrk1a not always being overexpressed.
Staphylococcus aureus lipid factors modulate melanoma cell clustering and invasion
Summary: S. aureus supernatant increases invasion of melanoma cells in zebrafish and is likely to be mediated by the production of bacterial lipids.
Deficient GATA6–CXCR7 signaling leads to bicuspid aortic valve
Summary: Gata6 haploinsufficiency causes bicuspid aortic valve and congenital heart defects associated with reduced second heart field progenitor differentiation, proliferation and migration, impaired endocardial cushion development and deficient CXCR7 signaling.
The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype
Summary: An intrinsically hybrid epithelial/mesenchymal phenotype confers dynamic remodeling of cell-cell junctions and an E-cadherin-indifferent metastatic capacity to the 4T1 model of stage IV breast cancer.
eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle
Summary: Drosophila eEF1α2, a well-characterized translation elongation factor, is required for age-related muscle fiber homeostasis, possibly independent of its role in protein synthesis.
FIRST PERSON
CORRECTION
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
