Issues
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RESEARCH ARTICLES
Deficient GATA6–CXCR7 signaling leads to bicuspid aortic valve
Summary: Gata6 haploinsufficiency causes bicuspid aortic valve and congenital heart defects associated with reduced second heart field progenitor differentiation, proliferation and migration, impaired endocardial cushion development and deficient CXCR7 signaling.
The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype
Summary: An intrinsically hybrid epithelial/mesenchymal phenotype confers dynamic remodeling of cell-cell junctions and an E-cadherin-indifferent metastatic capacity to the 4T1 model of stage IV breast cancer.
eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle
Summary: Drosophila eEF1α2, a well-characterized translation elongation factor, is required for age-related muscle fiber homeostasis, possibly independent of its role in protein synthesis.
FIRST PERSON
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modelling
The ISSCR provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Subject collection: Building advocacy into research
DMM’s series - Building advocacy into research - features interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types, with the aim of supporting the highest quality research for the benefit of all patients affected by disease.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.