Issues

Summary: Negative data are often not published or shared, despite their immense value to scientific progression. Here, we outline some initiatives that aim to encourage the dissemination of all scientific results.

Summary: This Review provides an overview of the current knowledge on both the causes and consequences of dNTP pool perturbations in cancer cells, together with their impact upon genome stability.

Summary: Knock-in mouse models of AMPK target proteins deepen our understanding of AMPK biology, revealing new insights and complexities that impact related human disease.

Editor's choice: Using in vitro and in vivo models, this study identifies an important role for CCL2–CCR2 signaling in skeletal muscle wasting associated with breast cancer, with important implications for therapeutic targeting.

Summary: In a mouse model of reduced fetal growth demand, the placenta receives diminished blood flow via the umbilical artery and lowers its nutrient transfer capacity towards the end of gestation.

Summary: A deleterious variant of INTS1, the core subunit of the Integrator complex, causes severe sleep disturbances in humans.

Summary: iPSC-derived cardiomyocytes with the MYH7 R403Q variant show conduction slowing, increased spatial dispersion of repolarization and reduced expression of some rhythmonome proteins, suggesting a biophysical basis for arrhythmia in hypertrophic cardiomyopathy.

Summary: Using three regimes of γ-irradiation, a single 10 Gy dose was found to be the most refined method of inducing acute salivary gland injury in a mouse model to study the effects of head and neck cancer radiotherapy.

Summary: This research uncovers distinct functional classes for oncogenic Ras variants in a C. elegans model, including distinctions in their response to genetic modifiers that function in neighboring cells.

Summary: The BCG vaccine induces bladder cancer clearance by recruiting and polarizing macrophages towards a pro-inflammatory state, directly inducing apoptosis through TNF signaling, adding an extra step to the BCG-induced tumor immunity model.

Summary: Deficiency of the ribosomal rescue factor HBS1L causes retinal degeneration in both a human patient and hypomorph mice, and proteomic profiling reveals the underlying disruption of disc morphogenesis and photoreceptor cell function.

Summary: Retinal damage was experimentally induced in rhesus monkeys by intravitreal injection of N-methyl-D-aspartate (NMDA). Optical coherence tomography and electroretinography examinations showed similarities with human retinal diseases.

Summary: Gfpt1 deficiency only in skeletal muscles triggers the unfolded protein response. Maladaptive unfolded protein response due to suppressed autophagy fails to eliminate protein aggregates and provokes apoptosis in skeletal muscles.