Issues
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Cover image
Cover Image
Cover: Transmission electron micrograph of an abnormal myelin ultrastructure, including splitting of myelin, is found in the central nervous system white matter of DMDmdx mice, a mouse model for Duchenne muscular dystrophy. See article by Arreguin et al. (dmm050115). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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PERSPECTIVE
Modelling the micro- and macro- environment of pancreatic cancer: from patients to pre-clinical models and back
Summary: The micro- and macro- environments of pancreatic cancer are complex. Better recapitulation of this heterogeneity in pre-clinical mouse models is essential to improve treatment options for this dismal disease.
AT A GLANCE
Degron tagging for rapid protein degradation in mice
Summary: We review recent applications of degron tagging in mouse models, focusing on the challenges and opportunities for using this technology to rapidly degrade proteins of interest in mammalian tissues.
REVIEW
Molecular functions of ANKLE2 and its implications in human disease
Summary: The scaffolding protein ANKLE2 is conserved throughout animals, with important roles in cell division and brain development. Disruption of ANKLE2 function is associated with several disease states.
EDITOR'S CHOICE
RESEARCH ARTICLES
Dmdmdx mice have defective oligodendrogenesis, delayed myelin compaction and persistent hypomyelination
Summary: The Dmdmdx mouse model for Duchenne muscular dystrophy mouse reveals suppressed production of oligodendrocyte progenitor cells from stem cell niches, altered dynamics of oligodendroglia in white matter and aberrant myelin ultrastructure.
The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy
Summary: BALB/c.mdx62 mice are a novel model of Duchenne muscular dystrophy with a deletion in exon 62 of the Dmd gene, and exhibit dystrophic skeletal muscle pathology and an associated bone phenotype.
HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells
Editor's choice: Mechanical stimulation of retinal pigment epithelial cells in vitro and in a mouse model increased the expression of VEGFA and other angiogenesis-related genes in a HIF-1α-dependent manner.
Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy
Summary: Using a Drosophila high-sucrose diet model, the study shows that a disrupted PINK1–PRKN pathway underlies the dysfunctional mitochondrial dynamics in diabetic nephropathy and demonstrates a potential therapeutic intervention.
In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes
Summary: A computer model of stem-cell derived cardiomyocytes was used to map the subcellular electro-mechano-energetics onto the mechanism of action of levosimendan, the oxygen consumption rate and relaxation dysfunction in ischemia and reperfusion.
Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability
Summary: Variants of O-GlcNAc transferase are associated with intellectual disability. A mouse model carrying an O-GlcNAc transferase variant has altered O-GlcNAc homeostasis, reduced mass and microcephaly.
Taurine activates the AKT–mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy
Summary: A 3D muscle model reveals the therapeutic potential of taurine in countering steroid myopathy and enhancing muscle function, and suggests a combined therapeutic approach for patients on corticosteroids or with adrenal tumors.
FIRST PERSON
CORRECTION
Correction: OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
DMM publishes perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
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