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Summary: The micro- and macro- environments of pancreatic cancer are complex. Better recapitulation of this heterogeneity in pre-clinical mouse models is essential to improve treatment options for this dismal disease.


Summary: We review recent applications of degron tagging in mouse models, focusing on the challenges and opportunities for using this technology to rapidly degrade proteins of interest in mammalian tissues.


Summary: The scaffolding protein ANKLE2 is conserved throughout animals, with important roles in cell division and brain development. Disruption of ANKLE2 function is associated with several disease states.



Summary: The Dmdmdx mouse model for Duchenne muscular dystrophy mouse reveals suppressed production of oligodendrocyte progenitor cells from stem cell niches, altered dynamics of oligodendroglia in white matter and aberrant myelin ultrastructure.

Summary: BALB/c.mdx62 mice are a novel model of Duchenne muscular dystrophy with a deletion in exon 62 of the Dmd gene, and exhibit dystrophic skeletal muscle pathology and an associated bone phenotype.

Editor's choice: Mechanical stimulation of retinal pigment epithelial cells in vitro and in a mouse model increased the expression of VEGFA and other angiogenesis-related genes in a HIF-1α-dependent manner.

Summary: Using a Drosophila high-sucrose diet model, the study shows that a disrupted PINK1–PRKN pathway underlies the dysfunctional mitochondrial dynamics in diabetic nephropathy and demonstrates a potential therapeutic intervention.

Summary: A computer model of stem-cell derived cardiomyocytes was used to map the subcellular electro-mechano-energetics onto the mechanism of action of levosimendan, the oxygen consumption rate and relaxation dysfunction in ischemia and reperfusion.

Summary: Variants of O-GlcNAc transferase are associated with intellectual disability. A mouse model carrying an O-GlcNAc transferase variant has altered O-GlcNAc homeostasis, reduced mass and microcephaly.

Summary: A 3D muscle model reveals the therapeutic potential of taurine in countering steroid myopathy and enhancing muscle function, and suggests a combined therapeutic approach for patients on corticosteroids or with adrenal tumors.



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