Issues
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Cover image
Cover Image
Cover: Drosophila third instar larval brain stained for aPKC (magenta), Elav (green, neurons), lamin (cyan, nuclear envelope), DNA was stained using DAPI (blue). The large magenta cells are neural stem cells, whereas the smaller green cells are differentiating neuronal lineages produced by an asymmetrically dividing stem cell. The image shows a partial z-projection. See article by Link et al. (dmm050297). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Synergistic modelling of human disease
Summary: Increasingly complex research questions can be answered by using complimentary models of human disease. These systems can build a holistic representation of human disease and enable better translation to the clinic.
SPECIAL ARTICLE
Stem cell modeling of nervous system tumors
Summary: The application of human stem cell engineering to nervous system tumor modeling affords unique opportunities to study the cellular origins of tumors, examine cancer evolution and identify future therapeutic targets.
REVIEW
Shared features in ear and kidney development – implications for oto-renal syndromes
Summary: This Review summarizes the developmental pathways shared between inner ear and kidney formation and explores the mechanisms underlying oto-renal syndromes.
EDITOR'S CHOICE
RESEARCH ARTICLES
A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis
Summary: This work classifies how cells respond when their splicing is broadly disrupted, and explores the relevance of this response to cell-type-specific phenotypes.
Motor protein Kif6 regulates cilia motility and polarity in brain ependymal cells
Summary: Kif6 localizes to the axonemes of ependymal cells. In vitro analysis showed that Kif6 moves along microtubules and that, in mouse, its loss decreases cilia motility and cilia-driven flow, resulting in hydrocephalus.
Postnatal Zika virus infection leads to morphological and cellular alterations within the neurogenic niche
Summary: Following intracranial Zika virus infection in postnatal mice, the formation of the neurogenic niche within the dentate gyrus is affected and subgranular zone development is severely impaired.
PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis
Summary: Cerebellar organoids recapitulate in vivo processes of regionalisation and SHH signalling, and offer new insight into early pathophysiological events of medulloblastoma tumorigenesis without the use of animal models.
RESOURCES & METHODS
A Zika virus protein expression screen in Drosophila to investigate targeted host pathways during development
Editor's choice: Expression of Zika virus proteins in Drosophila causes tissue-specific phenotypes, suggesting that they interact or inhibit specific host pathways during development to cause disease.
FIRST PERSON
PREPRINT HIGHLIGHTS
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health

Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine

In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.