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EDITORIAL

Summary: Increasingly complex research questions can be answered by using complimentary models of human disease. These systems can build a holistic representation of human disease and enable better translation to the clinic.

SPECIAL ARTICLE

Summary: The application of human stem cell engineering to nervous system tumor modeling affords unique opportunities to study the cellular origins of tumors, examine cancer evolution and identify future therapeutic targets.

REVIEW

Summary: This Review summarizes the developmental pathways shared between inner ear and kidney formation and explores the mechanisms underlying oto-renal syndromes.

EDITOR'S CHOICE

RESEARCH ARTICLES

Summary: This work classifies how cells respond when their splicing is broadly disrupted, and explores the relevance of this response to cell-type-specific phenotypes.

Summary: Kif6 localizes to the axonemes of ependymal cells. In vitro analysis showed that Kif6 moves along microtubules and that, in mouse, its loss decreases cilia motility and cilia-driven flow, resulting in hydrocephalus.

Summary: Following intracranial Zika virus infection in postnatal mice, the formation of the neurogenic niche within the dentate gyrus is affected and subgranular zone development is severely impaired.

Summary: Cerebellar organoids recapitulate in vivo processes of regionalisation and SHH signalling, and offer new insight into early pathophysiological events of medulloblastoma tumorigenesis without the use of animal models.

RESOURCES & METHODS

Editor's choice: Expression of Zika virus proteins in Drosophila causes tissue-specific phenotypes, suggesting that they interact or inhibit specific host pathways during development to cause disease.

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