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RESEARCH ARTICLES

Summary: This study describes a novel in vivo zebrafish model of neural Fyn kinase activation and identifies Stat3 signaling as a downstream Fyn effector in dopaminergic neuron degeneration and neuroinflammation.

Editor's choice: Zebrafish nf2a/b genes are expressed in tissues involved in neurofibromatosis type II (NF-2). Inducible knockout of nf2a/b triggers the development of a spectrum of tumors, mirroring the manifestations observed in patients with NF-2.

REVIEW COMMONS TRANSFER

Summary: This study finds a pro-oncogenic role for FOXO6, downstream of glioblastoma-associated elevated FOXG1, in controlling quiescence exit of mouse neural stem cells.

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