Issues

Summary: The 2024 Nobel Prize in Physiology or Medicine has been awarded for the discovery of miRNAs; the groundwork was laid by investigating the timing of developmental events in nematodes.

Summary: Few genes have been proven as causal for congenital heart defects (CHDs). Here, we discuss ways to improve the molecular diagnosis of CHDs using mouse models to validate potential CHD genes.

Summary: High-fat and high-sucrose diets for 6 months can synergistically induce severe dyslipidemia and RPD-like retinal lesions (mainly lipid droplets around RPE cells) without obesity in male Chinchilla rabbits.

Summary: In a rodent model of cisplatin-induced pain in adult survivors of paediatric cancer, early-life cisplatin exposure induces neuroinflammation via NGF-mediated nociceptor sensitization, leading to delayed onset of pain.

Summary: This study shows, for the first time, a role of reduced eIF2α phosphorylation in the early-onset primary dystonia DYT-PRKRA and in cerebellar development in a mouse model.

Summary: This work employs mouse genetic models to demonstrate that Hippo signaling deficiency suppresses lung airway mucous cell metaplasia induced by lipopolysaccharide or p53 deletion.

Summary: Amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson's disease are distinct neurological disorders with shared genetic mutations and pathologies. Here, we identified disease-specific and overlapping transfer RNA-derived small RNAs.

Summary: This study provides insight into the contribution of SNARE-dependent exocytosis from mutant HTT-expressing astrocytes to neuropathological changes in a mouse model of Huntington's disease.

Editor's choice: A comprehensive comparative analysis of tools and approaches to study lipid droplet dynamics in the zebrafish larval liver under physiological and pathological conditions.