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Issues

EDITORIAL

Summary: We welcome five new Editorial Advisory Board members, who help to expand our expertise in areas of cutting-edge disease research and maintain our journal's high publishing standards.

PERSPECTIVE

Summary: We provide an overview of mitochondrial and metabolic aberrations encountered in inflammatory bowel disease (IBD) and discuss potential immunometabolic therapies as emerging novel approaches for IBD.

REVIEW

Summary: Dominantly inherited myopathies and muscular dystrophies affect various skeletal muscle functions, from structural components to protein homeostasis. Understanding their complex, diverse mechanisms is crucial for developing effective therapies.

EDITOR'S CHOICE

RESEARCH ARTICLES

Summary: This study reveals the sex disparity in zebrafish liver cell proliferation following liver resection and how this disparity is regulated by sex hormone receptors and the calcium-binding protein S100A1.

Summary: This study utilizes high-throughput mRNA sequencing to identify genes and pathways involved in the initiation and progression of endometriosis-like lesions in a mouse model of endometriosis.

Summary: Pre-clinical studies of post-traumatic osteoarthritis are dominated by using the destabilisation of the medial meniscus (DMM) model. Here, we describe the transcriptomic similarity between the DMM mouse model and that for the more-rapid and reproducible mechanical rupture of the anterior cruciate ligament.

Editor's choice: Motor symptoms, muscle weakness and muscle atrophy have been reported in patients with Lafora disease. Here, using a mouse model, we demonstrate that motor deficits in Lafora disease are caused by neuropathic and myopathic alterations.

RESOURCES & METHODS

Summary: By compiling data on primary cilia-associated genes, their corresponding mouse and zebrafish alleles, and phenotypes, we provide an editable, Excel-based tool to help researchers identify and prioritize genes for study.

Summary: This work introduces an improved method to model heart failure in mouse models of Duchenne muscular dystrophy and comprehensively describes underlying cellular and physiologic mechanisms using advanced imaging techniques.

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