Issues
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Cover image
Cover Image
Cover: The fluorescence image shows the morphology and innervation pattern of the neuromuscular junction in the gastrocnemius muscle of a mouse model with Lafora disease (a rare fatal neurodegenerative disorder), aged 10 months. Postsynaptic acetylcholine receptors are stained red with Alexa Fluor 594-conjugated α-bungarotoxin; presynaptic nerve fibres and terminals are visually marked with anti-neurofilament and anti-synapsin-1 antibodies and stained in green. See article by Shukla et al. (dmm050905). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Welcoming new Editorial Advisory Board members
Summary: We welcome five new Editorial Advisory Board members, who help to expand our expertise in areas of cutting-edge disease research and maintain our journal's high publishing standards.
PERSPECTIVE
Immunometabolism and mitochondria in inflammatory bowel disease: a role for therapeutic intervention?
Summary: We provide an overview of mitochondrial and metabolic aberrations encountered in inflammatory bowel disease (IBD) and discuss potential immunometabolic therapies as emerging novel approaches for IBD.
REVIEW
Dominantly inherited muscle disorders: understanding their complexity and exploring therapeutic approaches
Summary: Dominantly inherited myopathies and muscular dystrophies affect various skeletal muscle functions, from structural components to protein homeostasis. Understanding their complex, diverse mechanisms is crucial for developing effective therapies.
EDITOR'S CHOICE
RESEARCH ARTICLES
Sex hormone receptors, calcium-binding protein and Yap1 signaling regulate sex-dependent liver cell proliferation following partial hepatectomy
Summary: This study reveals the sex disparity in zebrafish liver cell proliferation following liver resection and how this disparity is regulated by sex hormone receptors and the calcium-binding protein S100A1.
RNA sequencing reveals molecular mechanisms of endometriosis lesion development in mice
Summary: This study utilizes high-throughput mRNA sequencing to identify genes and pathways involved in the initiation and progression of endometriosis-like lesions in a mouse model of endometriosis.
Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models
Summary: Pre-clinical studies of post-traumatic osteoarthritis are dominated by using the destabilisation of the medial meniscus (DMM) model. Here, we describe the transcriptomic similarity between the DMM mouse model and that for the more-rapid and reproducible mechanical rupture of the anterior cruciate ligament.
Neuromuscular junction dysfunction in Lafora disease
Editor's choice: Motor symptoms, muscle weakness and muscle atrophy have been reported in patients with Lafora disease. Here, using a mouse model, we demonstrate that motor deficits in Lafora disease are caused by neuropathic and myopathic alterations.
RESOURCES & METHODS
A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research
Summary: By compiling data on primary cilia-associated genes, their corresponding mouse and zebrafish alleles, and phenotypes, we provide an editable, Excel-based tool to help researchers identify and prioritize genes for study.
Functional cardiac consequences of β-adrenergic stress-induced injury in a model of Duchenne muscular dystrophy
Summary: This work introduces an improved method to model heart failure in mouse models of Duchenne muscular dystrophy and comprehensively describes underlying cellular and physiologic mechanisms using advanced imaging techniques.
FIRST PERSON
PREPRINT HIGHLIGHTS
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health
Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue is Monday 20 January 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK.
New Special Issue: Translating Multiscale Research in Rare Disease. Edited by Monica Justice, Monkol Lek, Karen Liu and Kate Rauen.
This special issue features original Research, Resources & Methods and Review-type articles that aim to interrogate the mechanisms of rare diseases to foster meaningful clinical progress in their diagnosis and treatment.
The role of the International Society for Stem Cell Research guidelines in disease modelling
The International Society for Stem Cell Research (ISSCR) provides comprehensive guidelines and standards for using human stem cells in biomedical research. In this Editorial, Cody Juguilon and Joseph Wu discuss how and why these should be incorporated in disease modelling research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.