Issues

Summary: The Mexican Biobank captures biological factors at a nation-wide scale for the first time in Latin America. It is an inspiring example for leading such initiatives in the Global South.

Summary: We propose a standardization of criteria for drug screening and evaluation in zebrafish muscle disease models, with the goal of improving experimental rigor, reproducibility and translation.

Summary: We review how well-established and emerging Xiphophorus fishes and their interspecies hybrids can be used for studying human diseases, to highlight research opportunities enabled by these unique models.

Summary: A Lyn conditional knockout mouse mammary tumour model shows little effect of knocking out LYN kinase in tumour cells but suggests a link between Lyn-expressing B cells and tumour growth inhibition.

Editor's choice: eNOS is essential during cardiogenesis and null mutants frequently die during embryogenesis or at birth. Cardiovascular defects in mildly affected adult survivors can be traced back to intrauterine life.

Summary: A murine model of post-traumatic stress disorder (PTSD)-induced bone loss serves as a valuable tool to investigate the underlying mechanisms of osteoporosis associated with PTSD.

Summary: The transcriptional signature of zebrafish larvae infected with Shigella flexneri identifies acod1 and gpr84 as inducible factors that play a significant role in S. flexneri infection control.

Summary: We describe optimized protocols to generate organoid cultures from mouse esophageal and tongue epithelia and patient-derived esophageal samples. We also establish a co-culture model to assess CD8⁺ T cell-mediated tumor killing in patient samples.

Summary: Distinct 3D human skin models with phenotypic features of the inflammatory skin diseases psoriasis and atopic dermatitis can be reliably used to test novel treatment strategies.