Issues

Summary: DMM announces the winners of the DMM Outstanding Paper Prize for Research and Resource articles published in 2022.

Summary: Integrating bioethical frameworks and methodologies with biomedical research can have a key positive influence on the research's societal outcomes.

Summary: Studies in model organisms have shown that age-onset intestinal barrier dysfunction is linked to systemic health decline. Targeting intestinal barrier integrity is, therefore, a promising approach to prolong health span.

Summary: Although chikungunya virus (CHIKV) cases are rising globally, therapeutic options remain extremely limited. Here, we provide an overview of CHIKV pathogenesis and explore recent advances in strategies to prevent and treat infections.

Summary: Antimicrobial peptides are important immune molecules to fight microbes that are upregulated upon aging. Our results suggest that their upregulation upon aging is likely a consequence of aging, rather than a cause.

Summary: A Down syndrome mouse mapping panel shows that triplicated Dyrk1a plays a sex-specific role in some skeletal phenotypes. Triplicated genes may interact and cause improved or worsened skeletal measurements.

Editor's choice: Zebrafish Prdm1a proline/serine-rich and zinc finger domains are required to regulate fin induction, outgrowth and anterior/posterior patterning. Human PRDM1 variants containing disruptions in these domains cause split hand/foot malformation.

Summary: In vivo analysis in Drosophila, combined with in silico analysis of human genetic variants, reveals that Tribbles, which is involved with cell growth and division, metabolism, inflammation and cancer, also controls body weight and sleep.

Summary: Yeast studies provide biochemical data arguing for the pathogenicity of m.8950G>A, m.9025G>A and m.9029A>G, and neutral character of m.8843T>C, m.9016A>G, m.9058A>G, m.9139G>A and m.9160T>C, variants in MT-ATP6.

Summary: Mutations affecting the C-terminus of DVL1, a protein involved in Robinow syndrome, alter the balance of canonical and non-canonical Wnt signaling in the chicken limb and Drosophila wing.

Summary: Human chromosome 21 genes modulate Sonic hedgehog signaling, a pathway essential for organ development that is dysregulated in Down syndrome.

Summary: Pathways involved in regenerative responses may also promote tumorigenesis; however, the fibroblast-derived EGF ligand neuregulin 1 protects the intestinal epithelium from injury, but does not support tumorigenic growth.

Summary: We introduce new models for studying axon degeneration with high spatiotemporal resolution, revealing that skin-resident immune cells known as Langerhans cells engulf axonal debris in zebrafish skin.

Summary: The vascular abnormalities in a zebrafish genetic model of hereditary haemorrhagic telangiectasia were prevented by synergistic inhibition of the MEK and mTOR pathways downstream of Vegf, suggesting a potential novel therapeutic approach.

Summary: The Mouse Models of Human Cancer database (MMHCdb) is a comprehensive resource for knowledge about diverse in vivo mouse models of human cancer.