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A MODEL FOR LIFE
Hacking hematopoiesis – emerging tools for examining variant effects
Summary: Thousands of genomic loci have been linked to hematopoietic traits and diseases, yet many await functional validation. Here, we discuss recent advances in genome editing and challenges in using these techniques to assess variant function in primary hematopoietic cells.
Translating non-coding genetic associations into a better understanding of immune-mediated disease
Summary: The success of genetic studies provides a unique opportunity to better understand immune-mediated disease mechanisms. To achieve this, however, knowledge of where disease-associated variants lie must be translated into an understanding of how they cause disease.
HuR modulation counteracts lipopolysaccharide response in murine macrophages
Summary: This extensive study provides progress in the development of synthetic modulators of HuR functions, their genome-wide mechanism of action and their activity as anti-inflammatory agents.
Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency
Summary: This study shows, for the first time, a role for NLGN3 in GnRH neuritogenesis and reveals a common genetic mechanism between GnRH deficiency and autism, by applying a combined multiomic approach.
FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways
Summary: Limb defects in Robinow syndrome are associated with mutations in FZD2. Using mouse models, we show that FZD2 is causative, and controls limb development via both canonical and non-canonical Wnt pathways.
Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse
Summary: We identify a dual mechanism of spina bifida in Zic2 mutant mice – a possible paradigm for multifactorial human defects. BMP overactivation prevents neuroepithelial bending, whereas RhoA overactivation causes actomyosin accumulation.
Activated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae
Summary: This study uses zebrafish embryos and homology-directed gene editing to investigate the effect of activated PI3 kinase delta syndrome 1 mutations on innate immune cells, observing neutrophilia without defects in neutrophil differentiation or migration.
Impaired episodic-like memory in a mouse model of Alzheimer's disease is associated with hyperactivity in prefrontal–hippocampal regions
Summary: Using a preclinical Alzheimer's disease model, our work highlights that episodic memory impairment at early disease stage is associated with neuronal hyperactivity in specific medial prefrontal cortex and hippocampus regions.
A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis
Editor's choice: Our work using in vitro liver spheroid models consisting of both parenchymal and non-parenchymal cells shows a hepatoprotective role of peritumoral hepatic stellate cells in liver tumorigenesis.
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology
Summary: We describe an in vivo quantitative high-throughput screening strategy with C. elegans, designed to leverage and engage experience of the model organism community with screening and drug development resources.
Tellu – an object-detector algorithm for automatic classification of intestinal organoids
Summary: Description and demonstration of an automated easy-to-use online tool for classifying intestinal organoids to facilitate quantitative analyses of increasingly popular organoids.
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens
We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Registration is open now.
The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. For every Research Article and Review article that is published in one of our five journals a native tree is planted in a forest in the UK. Take a look at our virtual forest online now.
Propose a new workshop for 2025
Do you have an idea for a Workshop? If so, click here. We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
New drugs to squash the spread of malaria
In this Research Article, the Baum lab identify a new class of antimalarials to block Plasmodium gamete formation. This article has been highlighted as our Editor’s Choice, and you can find out more in our interview with first author Sabrina Yahiya.
The shifting culture of the scientific workforce – a change for women and girls in science
February 11 marks The International Day of Women and Girls in Science (IDWGS) a celebration of the achievements of female scientists, and a call to action for a culture shift in science. Click here to read more about the day