Issues

Summary: We review mouse models of fragile X-related disorders and discuss their advantages, limitations and use as preclinical models, as well as assess the challenges that remain to improve the reproducibility and translational value of these models.

Summary: The molecular, neurobehavioral and organ system characterization of a rat model of Schaaf-Yang syndrome provides insight into the consequences of a truncating mutation in the imprinted gene Magel2.

Summary: Low HER2 expression promotes in vitro transformation in a 3D breast cancer model through widespread increase in chromatin accessibility and the acquisition of stem-like phenotype.

Summary: Patient-specific variants in NFU1/NFU-1 affect motility and movement in C. elegans due to aberrant cholinergic signaling, but variants have different effects on presynaptic and postsynaptic function.

Summary: Loss of Shp1 in zebrafish impairs neutrophil and macrophage function and results in severe inflammation and lethality during the larval stage.

Editor's choice: A new class of antimalarials based on a N-[(4-hydroxychroman-4-yl)methyl]-sulphonamide scaffold potently prevents malaria parasite transmission to the mosquito by targeting the Plasmodium falciparum vacuole membrane protein Pfs16.