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RESEARCH ARTICLES

Summary: Neuroblastoma cells lacking MYCN amplification exhibit distinct subpopulations associated with differential gene expression programs and can interconvert between a state characterized by expression of neuronal genes and a de-differentiated state.

Summary: Nephrocyte-specific expression of APOL1 reference (G0) or risk alleles (G1, G2, G1G2) in Drosophila revealed APOL1-G2 to be most pathogenic in disrupting nephrocyte function and filtration structure, and implicates underlying dysfunctional autophagy.

Summary: The DE50-MD dog model of Duchenne muscular dystrophy shows a marked age-associated torque reduction following eccentric exercise; this biomarker is a strong candidate for objective measurement of muscle function for preclinical trials.

Summary: Human microglia-like cells heterozygous for three different NF1 gene mutations found in patients with neurofibromatosis type 1 show defects in P2X receptor activation, phagocytosis and motility.

Editor's choice: Cell-free hemoglobin (CFH) treatment of human kidney organoids serves as an in vitro model of sepsis-associated acute kidney injury. Treatment with ascorbate mitigated CFH-induced injury of kidney cells.

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