Issues
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Cover image
Cover Image
Cover: Patient and advocate voices are crucial for helping to set research priorities, address ethical concerns, influence decisions in funding, legislation and policy, promote health equity, and bring attention to the burdens faced by patients and their families. Perhaps the most important and effective way for disease researchers to engage with patients and advocates is to start by listening. In the spirit of listening, Disease Models & Mechanisms has launched a new series – ‘Building Advocacy into Research’. This series will feature interviews, ‘The Patient’s Voice’, with patients and advocates for a range of disease types. It is our hope that the series will provide patients and researchers alike with roadmaps for how to build strong ongoing partnerships, supporting the highest quality research for the benefit of all patients affected by disease. This image is by neilsmithillustration.co.uk and published under the CC-BY 4.0 license for this article.
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EDITORIAL
THE PATIENT'S VOICE
EDITOR'S CHOICE
RESEARCH ARTICLES
Differentiated neuroblastoma cells remain epigenetically poised for de-differentiation to an immature state
Summary: Neuroblastoma cells lacking MYCN amplification exhibit distinct subpopulations associated with differential gene expression programs and can interconvert between a state characterized by expression of neuronal genes and a de-differentiated state.
APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway
Summary: Nephrocyte-specific expression of APOL1 reference (G0) or risk alleles (G1, G2, G1G2) in Drosophila revealed APOL1-G2 to be most pathogenic in disrupting nephrocyte function and filtration structure, and implicates underlying dysfunctional autophagy.
Longitudinal assessment of skeletal muscle functional mechanics in the DE50-MD dog model of Duchenne muscular dystrophy
Summary: The DE50-MD dog model of Duchenne muscular dystrophy shows a marked age-associated torque reduction following eccentric exercise; this biomarker is a strong candidate for objective measurement of muscle function for preclinical trials.
Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia
Summary: Human microglia-like cells heterozygous for three different NF1 gene mutations found in patients with neurofibromatosis type 1 show defects in P2X receptor activation, phagocytosis and motility.
Ascorbate protects human kidney organoids from damage induced by cell-free hemoglobin
Editor's choice: Cell-free hemoglobin (CFH) treatment of human kidney organoids serves as an in vitro model of sepsis-associated acute kidney injury. Treatment with ascorbate mitigated CFH-induced injury of kidney cells.
FIRST PERSON
CORRECTION
Correction: Modulation of serotonin in the gut-liver neural axis ameliorates the fatty and fibrotic changes in non-alcoholic fatty liver
History of our journals

As our publisher, The Company of Biologists, turns 100 years old, read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
A new perspective on disease research
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