Issues
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Cover image
Cover Image
Cover: As an essential component of the dystrophin glycoprotein complex, dystroglycan is expressed in different tissues, and required for the proper development and maintenance of multiple systems and organs. The Drosophila stage 16 embryo shows high levels of dystroglycan (red) within muscle fibers (green), neurons, glia, epithelium and trachea, with levels being enriched at sites connecting muscles to tendons. Nuclei were stained with DAPI (blue). See article by Carney et al. (dmm049862). Cover courtesy of Andriy Yatsenko and Halyna Shcherbata, and licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Impactful disease research: a DMM year in review
Summary: Editor-in-Chief Liz Patton reflects on the achievements of DMM and looks to the future of the journal.
PERSPECTIVE
Parallel repair mechanisms in plants and animals
Summary: The biology underpinning wound repair in plants and animals is very different, but a search for parallels reveals several shared signals and analogous mechanisms that may offer valuable lessons across the two kingdoms.
REVIEW
Understanding and modeling nerve–cancer interactions
Summary: This Review summarizes what is known about the types of nerves in solid tumors, the experimental models used to study nerve–cancer interactions and the translational implications of these interactions.
EDITOR'S CHOICE
RESEARCH ARTICLES
Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila
Summary: The muscular dystrophy-associated dystrophin glycoprotein complex (DGC) functions as an integral component of multiple signaling pathways and is involved in stress-dependent regulation of gene expression.
Increased cysteine metabolism in PINK1 models of Parkinson's disease
Summary: Increased cysteine metabolism in Parkinson's disease models.
String/Cdc25 phosphatase is a suppressor of Tau-associated neurodegeneration
Summary: Using a Drosophila model of tauopathy, expressing Tau2N4R, we show that Stg/Cdc25 activity promotes Tau dephosphorylation and suppresses neurodegeneration in the fly, independently of Tau aggregation status.
Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish
Editor's choice: Obesity incidence is rising, resulting in increased occurrence of obesity-related cancers often occurring in a sex-specific manner. Here, we developed a zebrafish model to investigate the intersection between obesity, sex and melanoma.
Infiltrating circulating monocytes provide an important source of BMP4 at the early stage of spinal cord injury
Summary: Following a spinal cord injury, circulating monocytes highly express BMP4 and increase the infiltration of monocyte-derived macrophages, also with upregulated BMP4 expression, into the injured spinal cord.
Induction of pancreatic neoplasia in the KRAS/TP53 Oncopig
Summary: We induced and characterized pancreatic neoplasms in Oncopigs, observing similarities with human pancreatic cancer, and indicating potential use of the model in the development of diagnostics and therapeutics for pancreatic cancer.
Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability
Summary: Differentiating benign from misfolding, glaucoma-associated mutations in the myocilin olfactomedin domain has been a challenge. We show that the pathogenicity of myocilin variants can be predicted by a thermal stability cutoff of 47°C.
A kidney resident macrophage subset is a candidate biomarker for renal cystic disease in preclinical models
Summary: This study reveals that CD206+ kidney resident macrophages are directly associated with periods of rapid cyst formation and could serve as a biomarker for renal cystic disease in autosomal-dominant polycystic kidney disease patients.
Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsy
Summary: A new FLAG-malin mouse shows that E3 ubiquitin ligase malin associates with glycogen via laforin, uncovering molecular bases of unknown glycogen metabolism critical to Lafora disease and potentially common diseases.
FIRST PERSON
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens

We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
Louis Pasteur continues to shape the future of microbiology

To mark the 200th anniversary of the birth of Louis Pasteur, our Editorial Board member Serge Mostowy reflects on Pasteur’s legacy, and we interview Pascale Cossart, Head of the Bacteria-Cell Interactions Unit at Institut Pasteur.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Live imaging adult disease processes

The optical transparency of zebrafish larvae facilitates live imaging, but this transparency is not maintained into adulthood. To address this, Pui-Ying Lam’s Resource Article demonstrates the feasibility of imaging adult Danionella cerebrum. This article has been highlighted as our Editor’s Choice by Kristen Kwan.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.