Issues

Summary: Editor-in-Chief Liz Patton reflects on the achievements of DMM and looks to the future of the journal.

Summary: The biology underpinning wound repair in plants and animals is very different, but a search for parallels reveals several shared signals and analogous mechanisms that may offer valuable lessons across the two kingdoms.

Summary: This Review summarizes what is known about the types of nerves in solid tumors, the experimental models used to study nerve–cancer interactions and the translational implications of these interactions.

Summary: The muscular dystrophy-associated dystrophin glycoprotein complex (DGC) functions as an integral component of multiple signaling pathways and is involved in stress-dependent regulation of gene expression.

Summary: Increased cysteine metabolism in Parkinson's disease models.

Summary: Using a Drosophila model of tauopathy, expressing Tau2N4R, we show that Stg/Cdc25 activity promotes Tau dephosphorylation and suppresses neurodegeneration in the fly, independently of Tau aggregation status.

Editor's choice: Obesity incidence is rising, resulting in increased occurrence of obesity-related cancers often occurring in a sex-specific manner. Here, we developed a zebrafish model to investigate the intersection between obesity, sex and melanoma.

Summary: Following a spinal cord injury, circulating monocytes highly express BMP4 and increase the infiltration of monocyte-derived macrophages, also with upregulated BMP4 expression, into the injured spinal cord.

Summary: We induced and characterized pancreatic neoplasms in Oncopigs, observing similarities with human pancreatic cancer, and indicating potential use of the model in the development of diagnostics and therapeutics for pancreatic cancer.

Summary: Differentiating benign from misfolding, glaucoma-associated mutations in the myocilin olfactomedin domain has been a challenge. We show that the pathogenicity of myocilin variants can be predicted by a thermal stability cutoff of 47°C.

Summary: This study reveals that CD206⁺ kidney resident macrophages are directly associated with periods of rapid cyst formation and could serve as a biomarker for renal cystic disease in autosomal-dominant polycystic kidney disease patients.

Summary: A new FLAG-malin mouse shows that E3 ubiquitin ligase malin associates with glycogen via laforin, uncovering molecular bases of unknown glycogen metabolism critical to Lafora disease and potentially common diseases.