Issues

Summary: The 200th anniversary of the birth of Louis Pasteur is an opportunity to revisit the origins of microbiology and to consider Pasteur's impact on our ability to combat infectious disease.

Summary: This article summarizes the key points and action items that emerged from a virtual Keystone Symposium on advancing brain therapeutics.

Summary: Comprehensive morphological and molecular analysis of zebrafish transition zone mutants reveals differential roles of these proteins, as well as variable phenotypes within a clutch reminiscent of variability in ciliopathy patients.

Summary: Inhibition of cholesterol biosynthesis in microglia results in reactive microgliosis and subsequently astrogliosis in a mouse model of Smith–Lemli–Opitz syndrome, highlighting the role of lipid metabolism in regulating nervous system health and function.

Summary: We established a platform of neurodegeneration with iPSC-derived sensory neurons and investigated the connection between neurotoxicity and signaling pathways. Our results provide the potential for therapeutic targets in vincristine-induced neurodegeneration.

Summary: We developed a mouse model of 17q12 deletion syndrome, which phenocopies many of the features of the human disorder, including renal dysfunction, craniofacial, glucose homeostasis and brain abnormalities.

Summary: We used proteomics and electrophysiology to investigate how the common 1 kb deletion in CLN3 affects induced pluripotent stem cell-derived neuronal functions, and suggest pathways that may point to new therapeutic opportunities.

Summary: An evaluation of the serum inflammatory cytokine profile of the newly established DE50-MD dog model of Duchenne muscular dystrophy revealed potential biomarkers for future pre-clinical trials.

Summary: Human stem cell-derived neurons confirm a role for Wallerian-like degeneration in bortezomib-induced axonal neurotoxicity.

Summary: We report investigation of a new Down syndrome (DS) mouse model, Ts66Yah, with stronger construct and face validity for mimicking consequences of DS genetic overdosage than the premier (Ts65Dn) mouse model of DS.

Summary: Healthy photoreceptor cells release extracellular vesicles directly from their inner segment compartment. This process appears to be amplified in some photoreceptor degenerative models for disposal of mistrafficked proteins.

Editor's choice: Experimental imaging setup, materials and procedures for in vivo and longitudinal confocal imaging of the transparent adult vertebrate model Danionella cerebrum.