Issues

Summary: This Editorial explores how recent advances in schizophrenia genomics and longitudinal assessment of prodromal signs can be harnessed to develop and study mouse models that sufficiently reflect schizophrenia pathophysiology and support effective drug discovery.

Summary: We review evidence that aneuploid cells are eliminated in the presence of normal cells and the potential role of ribosomal protein gene haploinsufficiency in this cell competition process.

Summary: Pluripotent stem cell-derived differentiation cultures can recapitulate inner ear developmental progression in vitro, and their utility for applications in disease modelling and therapeutic trials will likely improve as ongoing research overcomes technical challenges.

Summary: In mice, the beneficial sex-dependent cognitive effects of xanthohumol under the conditions of a high-fat diet are associated with changes in hippocampal ceramides and diacylglycerols.

Summary: Differentiation of iPSCs derived from patients with esophageal atresia to mature esophageal organoids reveals a dysregulation of SOX2 and NKX2.1, key factors in esophagus and trachea development.

Summary: The concerted actions of Cdk8 and MED15 play critical roles in tight regulation of SREBP-dependent transcription in the nucleus and de novo lipogenesis in Drosophila.

Editor's choice: We infected K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2 and obtained comprehensive insights into COVID-19 pathogenicity in these two representative COVID-19 preclinical models.

Summary: Rapid changes in murine gene expression occur in irradiated salivary glands within hours of irradiation, and in non-irradiated contralateral glands, due to bystander effects.

Summary: A multi-omics approach shows that MAP kinase pathways are activated in response to DUX4 expression and contribute to DUX4-mediated cell death.