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REVIEWS

Summary: Lymphoid tissue fitness can determine disease severity and affect outcome by altering the course of immune responses. We discuss how lymphoid tissue function can impact disease progression during infections, chronic inflammatory conditions and cancer.

Summary: Recent evidence demonstrates that alternative mRNA splicing can influence tumour heterogeneity, its plasticity and a patient's response to therapeutic intervention. Here, we review the current knowledge of the role of alternative splicing in these processes.

RESEARCH ARTICLES

Summary: A gene–environment interaction involving the Vangl2 gene and sulfated glycosaminoglycans prevents mouse neural tube closure. Convergent extension shaping of the embryo is unaffected, implicating other mechanism(s) in this process.

Summary: Young adult zebrafish mutants and a mouse model of a genetic variant promoting early- and late-onset Alzheimer's disease, respectively, share changes in brain gene expression, indicating disturbance of oxidative phosphorylation.

Summary: Damage signaling from tumors mediated by JAK/STAT-activating Upd cytokines delays the Drosophila larva–pupa transition through co-option of a JAK/STAT developmental role in the prothoracic gland.

Summary: The zebrafish embryo is a quick, sensitive and powerful tool for evaluating the in vivo toxicity and efficacy of newly identified lipophilic anti-tuberculosis compounds formulated in nanoparticles.

Editor's choice: Using bleomycin-induced lung injury as a mouse model for idiopathic pulmonary fibrosis, this study identifies metabolomic and lipidomic changes in fibrosis reflecting higher energy demand, proliferation, tissue remodeling, collagen deposition and inflammation.

RESOURCE ARTICLE

Summary: This study presents an animal model that reflects the neurochemical pattern found in Parkinson's patients, the basis of the new and evolving catecholaldehyde hypothesis for the disease.

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