A MODEL FOR LIFE
AT A GLANCE
Summary: In this At a Glance article and poster, we explore the mechanisms of Notch signaling and discuss how the field has concluded that Notch signaling is a central determinant in bile duct formation and growth.
Summary: Chromosome rearrangements can be potent cancer drivers and effective therapeutic targets. Here, we review how genome-editing technologies can be exploited to engineer and study complex structural variants, and identify new treatment options.
Transforming growth factor β3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney
Summary: Our study describes the renal abnormalities of heterozygous Tgfb3-targeted mice and suggests that TGFβ3 is renoprotective and may counteract the activity of TGFβ1.
Summary: A mouse model of brittle cornea syndrome was created to elucidate molecular mechanisms underlying the pathology of this rare connective tissue disorder in which extremely thin corneas rupture, causing irreversible blindness.
Summary: The mdx52 mouse model of Duchenne muscular dystrophy lacks brain Dp427 and Dp140 dystrophins, and exhibits emotional, behavioral and learning phenotypes that are relevant for use in preclinical studies of the disorder.
Summary: dCubilin- or dAMN-mediated protein reabsorption in nephrocytes from hemolymph modulates Drosophila lifespan through regulating proteostasis and aging in muscle and brain tissues via the tele-proteostasis mechanism.
Impaired aerobic capacity and premature fatigue preceding muscle weakness in the skeletal muscle Tfam-knockout mouse model
Summary: A time-course study of mitochondrial and muscular dysfunctions in a mouse model of mitochondrial myopathy reveals that decreased resistance to fatigue together with decreased oxidative capacities arise ahead of muscle weakness.
Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice
Summary: Susceptibility to doxorubicin-induced nephropathy in 129S1/SvImJ mice is determined by a hierarchical two-hit process requiring the C6418T single-nucleotide polymorphism in the Prkdc gene and subsequent glomerular binding of plasminogen.
Mycobacteriophage–antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus
Summary: A zebrafish model of infection was developed to evaluate the in vivo cooperative activity of specific phages and antibiotics for the treatment of Mycobacterium abscessus infection.
Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan
Editor's choice: This study took advantage of Drosophila genetics to demonstrate how mild inflammation in early life can be a risk factor of life-long health via alteration of the gut microbiota.