It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation
Summary: New mechanisms of sporadic colorectal cancer initiation link gut dysbiosis with recent concepts of parainflammation, paligenosis and bystander effects to drive chromosomal instability and malignant transformation in colon epithelial cells.
Summary: Autosomal recessive osteopetrosis is a heterogeneous and rare bone disease for which effective treatments are still lacking for many patients. Here, we review the literature on clinical, preclinical and proof-of-concept studies.
Summary: This Special Article discusses cutting-edge approaches to counter aberrant phase transitions in disease using protein disaggregase- and RNA-based strategies.
Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells
Summary:Brca1−/− mammary tumours expressing Sox11 at high levels have more stem- and tumour-initiating cells, and are less proliferative, whereas tumours expressing Sox11 at lower levels become more proliferative and are capable of morphogenetic/metastatic growth.
Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model
Summary: A novel established mouse model carrying a heterozygous splicing human mutation in the Hnf1b gene exhibits phenotypes similar to those of patients with renal cysts and diabetes disease.