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REVIEWS

Summary: New mechanisms of sporadic colorectal cancer initiation link gut dysbiosis with recent concepts of parainflammation, paligenosis and bystander effects to drive chromosomal instability and malignant transformation in colon epithelial cells.

Summary: Autosomal recessive osteopetrosis is a heterogeneous and rare bone disease for which effective treatments are still lacking for many patients. Here, we review the literature on clinical, preclinical and proof-of-concept studies.

SPECIAL ARTICLE

Summary: This Special Article discusses cutting-edge approaches to counter aberrant phase transitions in disease using protein disaggregase- and RNA-based strategies.

RESEARCH ARTICLES

Summary:Brca1−/− mammary tumours expressing Sox11 at high levels have more stem- and tumour-initiating cells, and are less proliferative, whereas tumours expressing Sox11 at lower levels become more proliferative and are capable of morphogenetic/metastatic growth.

Summary: A novel established mouse model carrying a heterozygous splicing human mutation in the Hnf1b gene exhibits phenotypes similar to those of patients with renal cysts and diabetes disease.

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