Summary: Extracellular matrix dynamics are emerging as a key feature of metastasis. We discuss the changes in matrix composition of the liver metastatic niche, how these impact disease progression, and the approaches to study this topic.
Summary: MicroRNAs are capable of self-targeting, which has implications on their biogenesis, their canonical role in gene regulation and on cancer development.
Automated in vivo drug screen in zebrafish identifies synapse-stabilising drugs with relevance to spinal muscular atrophy
Summary: We report an automated and high-throughput screening platform to identify compounds relevant to motor neuron disease using younger, less-pigmented zebrafish embryos.
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome
Summary: We performed a genetic screen in Col4a1 mutant mice to elucidate the mechanisms contributing to Gould syndrome. Our results implicate FN1 as a genetic modifier of some, but not all, aspects of Gould syndrome.
An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton
Editor's choice: In a mouse model of achondroplasia, targeting an Fgfr3-activating mutation to immature osteoblasts led to osteopenia and induced craniofacial membranous bone defects.
Thiopurines correct the effects of autophagy impairment on intestinal healing – a potential role for ARHGAP18/RhoA
Summary: Analyses of HT29 cells after ATG16L1 knockdown reveal a novel biological mechanism for the association between the autophagy pathway and Crohn's disease, and could aid personalized medicine strategies in Crohn's disease therapy.
Summary: Embryonic movement post paralysis can partially recover specific aspects of joint development, which could inform therapeutic approaches to ameliorate the effects of restricted fetal movement in utero.
Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model
Summary: We established a prediabetic obese mouse model for studying sex dimorphism in peripheral neuropathy. Females retain early insulin sensitivity upon high-fat diet challenge, but develop the same degree of peripheral neuropathy as males.
Summary: We describe an integrated metabolomics and lipidomics method for analyzing metabolites in C. elegans using a single-sample preparation, which provides a robust way of obtaining comprehensive, high-quality metabolic data from biological samples.
Summary: We used a mass cytometry analysis pipeline to immunophenotype tumor immune infiltrate from two pancreatic and three breast cancer murine models, identifying a link to obesity in the E0771 breast cancer model.