Summary: Extracellular matrix dynamics are emerging as a key feature of metastasis. We discuss the changes in matrix composition of the liver metastatic niche, how these impact disease progression, and the approaches to study this topic.
Summary: MicroRNAs are capable of self-targeting, which has implications on their biogenesis, their canonical role in gene regulation and on cancer development.
Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model
Summary: We established a prediabetic obese mouse model for studying sex dimorphism in peripheral neuropathy. Females retain early insulin sensitivity upon high-fat diet challenge, but develop the same degree of peripheral neuropathy as males.
Summary: We used a mass cytometry analysis pipeline to immunophenotype tumor immune infiltrate from two pancreatic and three breast cancer murine models, identifying a link to obesity in the E0771 breast cancer model.