Issues
EDITORIAL
REVIEWS
The liver metastatic niche: modelling the extracellular matrix in metastasis
Summary: Extracellular matrix dynamics are emerging as a key feature of metastasis. We discuss the changes in matrix composition of the liver metastatic niche, how these impact disease progression, and the approaches to study this topic.
miRNA interplay: mechanisms and consequences in cancer
Summary: MicroRNAs are capable of self-targeting, which has implications on their biogenesis, their canonical role in gene regulation and on cancer development.
RESEARCH ARTICLE
Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model
Summary: We established a prediabetic obese mouse model for studying sex dimorphism in peripheral neuropathy. Females retain early insulin sensitivity upon high-fat diet challenge, but develop the same degree of peripheral neuropathy as males.
RESOURCE ARTICLE
High-dimensional immunotyping of tumors grown in obese and non-obese mice
Summary: We used a mass cytometry analysis pipeline to immunophenotype tumor immune infiltrate from two pancreatic and three breast cancer murine models, identifying a link to obesity in the E0771 breast cancer model.
FIRST PERSON
Virtual Meeting - Developmental Disorders: From Mechanism to Treatment
A collaboration between the Development and Disease Models & Mechanisms journal teams, this virtual Meeting will unite developmental biologists, human geneticists and clinical researchers to focus on building bridges from bench to clinic. Register your interest and find out more.
High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition
Vitamin B1 is shown to prevent nutrition-induced fatty liver in our current Editor’s choice by Hay Davir and his colleagues, when they use sheep as a large-animal model for studying the disease.
Find out more in an interview with the paper's first authors, Mugagga Kalyesubula and Ramgopal Mopuri.
Upcoming grant deadlines
Grants awarded by The Company of Biologists help scientists travel, attend events and host sustainable activities. Make a note of the upcoming application deadlines and find out more about the grants on offer:
DMM Conference Travel Grants
17 May 2021
Sustainable Conferencing Grants
17 May 2021
Travelling Fellowships
31 May 2021
Scientific Meeting Grants
4 June 2021
Call for papers - The RAS Pathway: Diseases, Therapeutics and Beyond
Our upcoming special issue is welcoming submissions until 3 May 2021. Guest-edited by Donita Brady (Perelman School of Medicine at the University of Pennsylvania, USA) and Arvin Dar (Icahn School of Medicine at Mount Sinai, USA), the issue will focus on targeting the RAS pathway.