Issues
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Cover image
Cover Image
Cover: Confocal microscopy image showing immunoreactive glial fibrillar acidic protein (GFAP; red) and amyloid precursor protein (APP; green) in rat primary control cultured astrocytes. See article by Wu et al. (dmm048929), which describes that exosomes derived from cholesterol-accumulated astrocytes can play an important role in trafficking APP and its cleaved product β-amyloid peptide, which can subsequently be taken up and influence the viability of neurons. Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITOR'S CHOICE
EDITORIAL
Hot to touch: the story of the 2021 Nobel Prize in Physiology or Medicine
Summary: This year’s Nobel Prize in Physiology or Medicine celebrates how even the most fundamental of science can lead to broad applications for improving health and wellbeing.
REVIEWS
Infant leukaemia – faithful models, cell of origin and the niche
Summary: In this Review we discuss how MLL gene rearrangements cooperate with transient facilitators presented by the foetal environment to initiate the development of infant leukaemia, and evaluate current leukaemia models.
Genetically altered animal models for ATP1A3-related disorders
Summary: This Review provides an overview of the animal models used to study the spectrum of ATP1A3-related disorders and discusses their contribution towards better understanding of pathological mechanisms and novel therapeutics.
RESEARCH ARTICLES
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
Summary: Cholesterol accumulation within astrocytes can influence secretion of exosomes containing β-amyloid-related peptides. Uptake of these exosomes can induce neurotoxicity, suggesting their potential implication in Alzheimer's disease pathogenesis.
Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection
Summary: Rapamycin, an mTOR inhibitor, with or without moxifloxacin, reduces lung inflammation and the number and size of caseating necrotic granulomas in Mycobacterium tuberculosis-infected C3HeB/FeJ mice.
Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis
Summary: We present a new mouse model of Charcot-Marie-Tooth disease type 2 Z and developmental delay, impaired growth, dysmorphic facies and axonal neuropathy syndrome with a Morc2a p.S87L mutation, exhibiting peripheral and central neuronal apoptosis.
Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse
Summary: We generated a mouse-adapted Japanese encephalitis virus (JEV) isolate to develop and characterize a mouse model of JEV infection, which could be a useful tool to screen antivirals and study JEV pathogenesis.
Integrative transcriptomic profiling of a mouse model of hypertension-accelerated diabetic kidney disease
Summary: Combining single-nucleus RNAseq with glomerular and cortical gene expression profiling can link kidney transcriptome signatures to specific cell types in an advanced mouse model of hypertension-accelerated diabetic kidney disease.
Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain
Summary: Using outbred deer mice, we show that the unfolded protein response operates as a modifier of propensity for body weight gain in a manner involving the regulation of an inflammatory response by skin fibroblasts.
Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes
Editor's choice: Comprehensive phenotyping shows that Dp1Tyb mice, a model of Down syndrome (DS), have a broad range of DS-related phenotypes and can be used to investigate causative genes and their pathological mechanisms.
RESOURCE ARTICLE
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3
Summary: Description of a flow cytometric methodology for the rapid detection and quantification of detergent-insoluble protein aggregates within cultured cells and transgenic zebrafish modelling spinocerebellar ataxia 3.
FIRST PERSON
DMM Journal Meeting 2023: Infectious Diseases Through an Evolutionary Lens

We are delighted to announce that our 2023 Journal Meeting ‘Infectious Diseases Through an Evolutionary Lens’ will be held from 17-19 October 2023 in London, UK. Find out more and register your interest here.
Louis Pasteur continues to shape the future of microbiology

To mark the 200th anniversary of the birth of Louis Pasteur, our Editorial Board member Serge Mostowy reflects on Pasteur’s legacy, and we interview Pascale Cossart, Head of the Bacteria-Cell Interactions Unit at Institut Pasteur.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Live imaging adult disease processes

The optical transparency of zebrafish larvae facilitates live imaging, but this transparency is not maintained into adulthood. To address this, Pui-Ying Lam’s Resource Article demonstrates the feasibility of imaging adult Danionella cerebrum. This article has been highlighted as our Editor’s Choice by Kristen Kwan.
Apply for a DMM Conference Travel Grant

Aimed at early-career researchers wanting to attend in-person and virtual meetings, the next application deadline for a DMM Conference Travel Grant is 3 March 2023. Find out more and hear from past recipients about their experience of the grant.