Issues

Summary: This year’s Nobel Prize in Physiology or Medicine celebrates how even the most fundamental of science can lead to broad applications for improving health and wellbeing.

Summary: In this Review we discuss how MLL gene rearrangements cooperate with transient facilitators presented by the foetal environment to initiate the development of infant leukaemia, and evaluate current leukaemia models.

Summary: This Review provides an overview of the animal models used to study the spectrum of ATP1A3-related disorders and discusses their contribution towards better understanding of pathological mechanisms and novel therapeutics.

Summary: Cholesterol accumulation within astrocytes can influence secretion of exosomes containing β-amyloid-related peptides. Uptake of these exosomes can induce neurotoxicity, suggesting their potential implication in Alzheimer's disease pathogenesis.

Summary: Rapamycin, an mTOR inhibitor, with or without moxifloxacin, reduces lung inflammation and the number and size of caseating necrotic granulomas in Mycobacterium tuberculosis-infected C3HeB/FeJ mice.

Summary: We present a new mouse model of Charcot-Marie-Tooth disease type 2 Z and developmental delay, impaired growth, dysmorphic facies and axonal neuropathy syndrome with a Morc2a p.S87L mutation, exhibiting peripheral and central neuronal apoptosis.

Summary: We generated a mouse-adapted Japanese encephalitis virus (JEV) isolate to develop and characterize a mouse model of JEV infection, which could be a useful tool to screen antivirals and study JEV pathogenesis.

Summary: Combining single-nucleus RNAseq with glomerular and cortical gene expression profiling can link kidney transcriptome signatures to specific cell types in an advanced mouse model of hypertension-accelerated diabetic kidney disease.

Summary: Using outbred deer mice, we show that the unfolded protein response operates as a modifier of propensity for body weight gain in a manner involving the regulation of an inflammatory response by skin fibroblasts.

Editor's choice: Comprehensive phenotyping shows that Dp1Tyb mice, a model of Down syndrome (DS), have a broad range of DS-related phenotypes and can be used to investigate causative genes and their pathological mechanisms.

Summary: Description of a flow cytometric methodology for the rapid detection and quantification of detergent-insoluble protein aggregates within cultured cells and transgenic zebrafish modelling spinocerebellar ataxia 3.