Issues
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Cover image
Cover Image
Cover: Photoreceptors in Drosophila adult compound eyes. The number of rhabdomeres (marked with phalloidin staining; green) within photoreceptors (outlined with Na+/K+-ATPase staining; magenta) is decreased in dDBT-deficient Drosophila compared to that in wild type, indicating that loss of dDBT activity results in neuronal damage. See article by Tsai et al. (dmm044750). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
FIRST PERSON
REVIEWS
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders
Summary: The APOE ε4 allele and female sex are among the strongest risk factors for late-onset Alzheimer's disease. We explore how the interplay between these factors affects risk for this and other age-related neurodegenerative diseases.
Integrating fish models in tuberculosis vaccine development
Summary: In this Review, we discuss how zebrafish (Danio rerio) and other fish models can complement the more traditional mammalian models in the development of novel vaccines against tuberculosis.
RESEARCH ARTICLES
Loss of the Drosophila branched-chain α-ketoacid dehydrogenase complex results in neuronal dysfunction
Summary: Loss of BCKDH activity in Drosophila recapitulates the neurological symptoms of patients with maple syrup urine disease. Metformin administration was found to alleviate developmental defects and aberrant behavior in the BCKDH mutant.
A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
Summary: Nonsense-mediated mRNA decay can be inhibited after completion of mammalian prenatal development without adverse effects in non-neurological, somatic tissues, indicating that such inhibition might be a viable therapeutic strategy.
Maltodextrin-induced intestinal injury in a neonatal mouse model
Summary: Using maltodextrin-dominant human infant formula feeding in combination with hypoxia, we developed a highly reproducible model of small intestinal injury in the neonatal mouse.
Generation and characterization of an Il2rg knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients
Summary: Syrian hamsters are an important rodent species for studying multiple human diseases. We describe the generation and characterization of a hamster strain that is defective in the XCSID-associated IL2RG gene.
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types
Summary: In p53- and nf1-deficient zebrafish, onset of MPNSTs, as well as diverse other tumors, is accelerated by loss of the suz12 tumor suppressor, accompanied by global reduction in H3K27me3 marks and increased Ras-Mapk signaling.
Nrf2/HO-1 mediates the neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury in rats
Editor's choice: We administered pramipexole (PPX) to rats after a traumatic brain injury (TBI) and evaluated various parameters, which indicate that the neuroprotective effects of PPX are mediated by activation of the Nrf2/HO-1 signaling pathway following TBI.
The transcription factor Maz is essential for normal eye development
Summary: Our study has uncovered Maz as an important regulator of eye development in humans and mice, striving to elucidate the role of this gene in eye abnormalities associated with the human ch16p11.2 microdeletions and microduplications.
Systemic and heart autonomous effects of sphingosine Δ4 desaturase deficiency in lipotoxic cardiac pathophysiology
Summary: Systemic versus heart autonomous functions of sphingosine Δ4 desaturase differentially regulate cardiac structure and function in a tissue-specific manner in Drosophila, where organ interplay mimics that observed in mammalian systems.
Call for Papers – Infectious Disease: Evolution, Mechanisms and Global Health

Showcase your latest research on our upcoming Special Issue: Infectious Disease: Evolution, Mechanisms and Global Health. This issue will be coordinated by DMM Editors Sumana Sanyal and David Tobin alongside Guest Editors Judi Allen and Russell Vance. The deadline for submitting articles to this Special Issue has been extended to Monday 24 February 2025.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate a DMM programme on antimicrobial resistance on 26 March 2025. Find out more and register to join us in March 2025 in Liverpool, UK. The final deadline to register is 28 February 2025.
It's about time: the heterochronic background for the 2024 Nobel Prize in Physiology or Medicine

In this Editorial, Bruce Wightman writes about the groundwork laid by investigating the timing of developmental events in nematodes which led to the 2024 Nobel Prize in Physiology or Medicine.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.