Issues
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Cover image
Cover Image
Cover: Drosophila adult gut displaying Yki-driven intestinal stem cell tumor (marked with GFP, green; TO-PRO-3 marks all nuclei). Gut from a 10-day-old untreated fly is shown. See article by Bajpai et al. (dmm044420). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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FIRST PERSON
REVIEWS
Temporal patterning in neural progenitors: from Drosophila development to childhood cancers
Summary: Temporal patterning is the mechanism by which neural progenitors change their competence and proliferative properties during development. Recent data suggest that co-opted temporal patterning could govern tumor growth in neural cancers with developmental origins.
Neuromuscular disease modeling on a chip
Summary: Modeling neuromuscular diseases is challenging due to their complex etiology and pathophysiology. Here, we review the cell sources and tissue-engineering procedures that are being integrated as emerging neuromuscular disease models.
RESEARCH ARTICLES
Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV
Summary: We show that loss of the lysosomal channel TRPML1, responsible for mucolipidosis IV, leads to delayed maturation of oligodendrocytes in early postnatal development, resulting in brain hypomyelination.
A lineage-tracing tool to map the fate of hypoxic tumour cells
Summary: Here, we developed and characterised a novel HIF-1α-Cre fusion protein to trace the progeny of hypoxic tumour cells in a temporal and spatially resolved manner using intravital microscopy.
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse
Summary: Following injury, constitutive activation of KRAS in the murine pancreas inhibits regeneration and instead promotes the formation of preneoplastic lesions by blocking Hedgehog signal transduction by forcing disassembly of the primary cilium.
Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome
Summary: Human TCF4, a bHLH transcription factor, is associated with intellectual disability and schizophrenia. Here, we propose a Drosophila model for human disease studies using the fruit fly TCF4 orthologue, Daughterless.
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia
Summary: Sole expression of the mutant frataxin G127V protein is sufficient for viability of the first Friedreich's ataxia point mutation mouse model, but induces premature senescence in isolated cells.
A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors
Summary: We demonstrate that, when fed to flies, TONDU peptide suppresses Yki-driven intestinal stem cell (ISC) tumors, and identify integrins as essential components of ISC tumorigenesis.
Silencing of CCR4-NOT complex subunits affects heart structure and function
Summary: Genome-wide association studies combined with in vitro human cardiac cell assays and a model organism suitable for heart studies in vivo connect CNOT1, CNOT7 and overall the CCR4-NOT complex to human heart disease and morbidity.
The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages
Summary: We have established a novel zebrafish infection model to investigate Toxoplasma replication in vivo, and demonstrate a key role for macrophages in parasite control.
Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of Ccn2
Summary: Postnatal deletion of Ccn2 in chondrocytes does not affect the development of post-traumatic osteoarthritis in mice.
RESOURCE ARTICLES
Rabbit model of Staphylococcus aureus implant-associated spinal infection
Summary: A model of post-surgical methicillin-resistant Staphylococcus aureus implant-associated spinal infection was created in rabbits, recapitulating acute infection as well as chronic low-burden infection, with structures suggestive of biofilm formation and bone remodeling.
A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
Editor's choice: This paper presents the MouseRefSWATH mouse reference spectral library as a standardized community resource for SWATH-mass spectrometry studies and the XenoSWATH pipeline for species-specific deconvolution of human xenograft proteomic data.
Sentinel interaction mapping – a generic approach for the functional analysis of human disease gene variants using yeast
Summary: Sentinel interaction mapping is a technique that employs systematic genetic interaction mapping to identify yeast-human genetic interactions, which can be used to rapidly functionalize human disease genes and their variants.
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery

We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops

For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review

Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
A new perspective on disease research
DMM publishes perspectives - peer-reviewed articles that provide expert analysis of a topic important to the disease research community. Read our collection from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.