Issues
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Cover image
Cover Image
Cover: Wild-type Drosophila eye imaginal epithelia showing Stat-GFP (red) and Actin (green) expression. See article by Harsh et al. (dmm040816). The authors observe that Drosophila eye imaginal discs carrying overexpression of Zika virus NS4A are smaller in size and show reduced expression of Stat-GFP, the in vivo reporter of JAK/STAT signaling, compared to wild type, while the overall architecture of the tissue (as shown by Actin) is unaffected. Stat-GFP expression in the antenna part of the eye tissue remains unaffected for wild-type Drosophila and those carrying Zika virus NS4A overexpression. Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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Casting a wide net: use of diverse model organisms to advance toxicology
Summary: This Editorial highlights the value of utilizing evolutionarily diverse model systems, including zebrafish, in basic toxicology research to investigate mechanisms of chemical-induced disease.
Membrane trafficking in health and disease
Summary: This At a Glance article and poster summarise the major intracellular membrane trafficking pathways and associated molecular machineries, and describe how defects in these give rise to disease in humans.
Zebrafish as a tool to study schizophrenia-associated copy number variants
Summary: Specific copy number variants significantly increase the risk of schizophrenia, although their mechanisms are incompletely understood. We review the zebrafish as a tool to begin to decipher the complex biology of these rare variants.
Zika virus non-structural protein NS4A restricts eye growth in Drosophila through regulation of JAK/STAT signaling
Summary: Our study provides evidence that Zika virus infection in Drosophila results in restricted growth of the developing eye and wing through regulation of JAK/STAT and Notch signaling, respectively.
DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma
Summary: Inflammation and Caspase-a activation occur early in a new zebrafish model for fibrolamellar carcinoma (FLC). Pharmacological inhibition of TNFα secretion and caspase-1 might be useful approaches to treat FLC patients.
Leptin and fractalkine: novel subcutaneous cytokines in burn injury
Summary: Burn injury is associated with increased levels of leptin and fractalkine in the skin. Signalling by these cytokines leads to macrophage accumulation and hypersensitivity to heat and mechanical stimuli.
Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis
Summary: This study describes a defatting cocktail that has been proven to function in three relevant steatotic human culture models without cytotoxicity, and which could be employed in the reduction of steatosis in donor livers during liver transplantation.
Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment
Editor's choice: Statin-induced upregulation of class II mutant LDLR does not cause acute endoplasmic reticulum (ER) stress and unfolded protein response induction, in spite of misfolded LDLR protein accumulation in the ER.
Gallbladder wall abnormality in biliary atresia of mouse Sox17+/− neonates and human infants
Summary: Metaplastic gland formation in gallbladder walls is seen in both human BA and the mouse Sox17-haploinsufficient BA model, indicating its contribution to the pathogenesis of human BA.
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is now open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, we will present the very latest advances in modelling human genetic disease.
A new call for papers is underway

Showcase your latest research in our upcoming special issue Translating Multiscale Research in Rare Disease, coordinated by DMM Editors Monica Justice, Karen Liu and Monkol Lek, and Guest Editor Kate Rauen. The deadline for submitting articles to the special issue is Monday 6 November 2023.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that aim to move heart failure to heart success by fundamentally addressing the roots of failure to identify curative strategies.
Adult zebrafish as advanced models of human disease

Editor-in-Chief Liz Patton and Editorial Board member Rich White discuss the unique advantages of adult zebrafish for studying human disease biology. Read the Open Access Editorial here.
The Forest of Biologists

The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Disease Models & Mechanisms a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.