Issues

Summary: This Editorial reflects on how the emergence of Big Data has affected traditional disease modeling over the past decade, and on DMM's place in this changing landscape.

Summary: This Review highlights the intersection between phosphoinositides and the enzymes that regulate their metabolism, which together are crucial regulators of myriad cellular processes and neurological disorders.

Summary: The zebrafish has become an increasingly attractive model for studying social behavior disorders. This Review summarizes relevant methods, established social deficit models, emerging technologies and the anatomical basis of sociality.

Summary: The authors provide evidence to show that a well-established Drosophila tumor model, caused by loss of apicobasal cell polarity, harbors a surprising degree of plasticity and evolvability along the temporal axis.

Summary: Pramipexole produced neurological recovery through mitochondrial-mediated survival pathways in ischemic stroke.

Summary: This paper reports that mast cells promote bone loss in an autoinflammatory disease model and that mast cell mediators were detected in autoinflammatory disease patient samples.

Summary: Evidence of protein aggregation and mitochondrial dysfunction were found in skeletal myocytes differentiated from ALS-patient induced pluripotent stem cells with the C9ORF72 mutation.

Summary: Vascular regression is observed prior to motor neuron loss in the FUS (1-359) mouse model of ALS, yet is not rescued by angiogenin treatment.

Summary: As IBD attempts to enter the era of precision medicine, our models provide an opportunity for the rapid and sophisticated determination of time course, cellular contributions and mechanisms of new drugs.

Editor's choice: Mild maternal hyperglycemia causes impaired glucose tolerance and metabolic alterations in wild-type neonatal offspring of INS^C93S transgenic pigs, a novel large animal model for mutant INS gene-induced diabetes of youth (MIDY).

Summary: This study offers proof-of-principle for a novel protocol to analyse gene expression in subsections of FFPE patient tissue, supporting the use of spontaneous canine mammary tumours as models for the human disease.

Summary: Ccdc151-knockout mice develop PCD with hydrocephalus, situs abnormalities and male infertility. Novel 3D microCT imaging analysis of the Ccdc151-lacZ reporter gene demonstrates Ccdc151 expression in ependymal cells.

Summary: The authors present a mouse model of acute hemorrhagic myocarditis and a refined technique of preclinical cardiac MR imaging to allow non-invasive detection of diffuse myocardial tissue damage accounting for iron deposition.