Issues
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Cover image
Cover Image
Cover: Testis from a heterozygous Ccdc151-lacZ mouse stained with X-gal/FeCN. The Ccdc151 gene is important for ciliary motility, and is expressed in testicular seminiferous tubules. Ccdc151 plays critical role in spermatogenesis: the authors show that, in the mouse model of primary ciliary dyskinesia disease, homozygous deletion of Ccdc151 in the germ line leads to azoospermia, while conditional deletion of Ccdc151 in adult animals results in abnormal sperm counts and defective sperm motility. See article by Chiani et al. (dmm038489). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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EDITORIAL
Disease Models & Mechanisms in the Age of Big Data
Summary: This Editorial reflects on how the emergence of Big Data has affected traditional disease modeling over the past decade, and on DMM's place in this changing landscape.
FIRST PERSON
REVIEWS
The expanding spectrum of neurological disorders of phosphoinositide metabolism
Summary: This Review highlights the intersection between phosphoinositides and the enzymes that regulate their metabolism, which together are crucial regulators of myriad cellular processes and neurological disorders.
The zebrafish subcortical social brain as a model for studying social behavior disorders
Summary: The zebrafish has become an increasingly attractive model for studying social behavior disorders. This Review summarizes relevant methods, established social deficit models, emerging technologies and the anatomical basis of sociality.
RESEARCH ARTICLES
Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors
Summary: The authors provide evidence to show that a well-established Drosophila tumor model, caused by loss of apicobasal cell polarity, harbors a surprising degree of plasticity and evolvability along the temporal axis.
Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke
Summary: Pramipexole produced neurological recovery through mitochondrial-mediated survival pathways in ischemic stroke.
Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis
Summary: This paper reports that mast cells promote bone loss in an autoinflammatory disease model and that mast cell mediators were detected in autoinflammatory disease patient samples.
C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells
Summary: Evidence of protein aggregation and mitochondrial dysfunction were found in skeletal myocytes differentiated from ALS-patient induced pluripotent stem cells with the C9ORF72 mutation.
Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model
Summary: Vascular regression is observed prior to motor neuron loss in the FUS (1-359) mouse model of ALS, yet is not rescued by angiogenin treatment.
Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease
Summary: As IBD attempts to enter the era of precision medicine, our models provide an opportunity for the rapid and sophisticated determination of time course, cellular contributions and mechanisms of new drugs.
Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
Editor's choice: Mild maternal hyperglycemia causes impaired glucose tolerance and metabolic alterations in wild-type neonatal offspring of INSC93S transgenic pigs, a novel large animal model for mutant INS gene-induced diabetes of youth (MIDY).
Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma
Summary: This study offers proof-of-principle for a novel protocol to analyse gene expression in subsections of FFPE patient tissue, supporting the use of spontaneous canine mammary tumours as models for the human disease.
Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia
Summary: Ccdc151-knockout mice develop PCD with hydrocephalus, situs abnormalities and male infertility. Novel 3D microCT imaging analysis of the Ccdc151-lacZ reporter gene demonstrates Ccdc151 expression in ependymal cells.
RESOURCE ARTICLE
Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging
Summary: The authors present a mouse model of acute hemorrhagic myocarditis and a refined technique of preclinical cardiac MR imaging to allow non-invasive detection of diffuse myocardial tissue damage accounting for iron deposition.
Call for papers – In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery

We invite you to submit your latest research to our upcoming special issue: In Vitro Models of Human Disease to Inform Mechanism and Drug Discovery, coordinated by DMM Editor Vivian Li (The Francis Crick Institute, London, UK), alongside Guest Editors Austin Smith (University of Exeter, UK) and Joseph Wu (Stanford University School of Medicine, USA).The deadline for submitting articles is 6 October 2025.
The Company of Biologists Workshops

For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
Fast & Fair peer review

Our sister journal Biology Open has recently launched the next phase of their Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. To learn more about BiO’s progress and future plans, read the Editorial by Daniel Gorelick, or visit the Fast & Fair peer review page.
Propose a new Workshop for 2027

We are currently seeking proposals for Workshops to be held in 2027. As one of the scientific organisers of a The Company of Biologists Workshop, your involvement will be focused on interdisciplinary, cutting-edge science and promoting new partnerships and collaborations. We focus on the logistics. Are you thinking about proposing a topic for one of our Workshops? Apply by Friday 30 May 2025.