Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.
Summary: Understanding how congenital kidney diseases arise is imperative to their treatment. Using Xenopus as a model will aid in elucidating kidney development and congenital kidney diseases.
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia
Summary: The Edaraddswh/swh rat has comparable ear, nose and throat (ENT) pathology to humans with hypohidrotic ectodermal dysplasia, and prenatal correction of EDAR signalling in EdaTa mice prevents ENT disease.
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal
Summary: Our work identified the driver mutations indispensable for PDAC induction from acinar cells in mature adults and established a novel PDAC animal model with increased similarity to human disease.
Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish
Summary: Mortality associated with AKI is in part due to limited treatments available to ameliorate injury. The authors identify a compound that accelerates AKI recovery and promotes cellular dedifferentiation.
Characterization of high- and low-risk hepatocellular adenomas by magnetic resonance imaging in an animal model of glycogen storage disease type 1A
Summary: High-risk adenomas display magnetic resonance imaging (MRI) features clearly distinguishable from those exhibited by low-risk adenomas, suggesting the possibility of applying MRI to humans for non-invasive diagnostic purposes.
Summary: The bromodomain-containing protein FS(1)H is required in the Drosophila fat body for normal lifespan and metabolic and immune function, largely via the insulin pathway.
CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene
Summary: The authors describe the creation of a mouse strain that reproduces a newly identified deletion mutation in a DMD patient in Russia, and present the characteristics of this new model.
Editor's choice: This study describes a novel 3D cell culture model that recapitulates key features of neuropathology in synucleinopathies, including large, nuclear-associated α-synuclein and ubiquitin-positive inclusions.