Issues
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Cover image
Cover Image
Cover: Confocal image of Xenopus laevis (frog) pronephros (orange) and nuclei (blue). Xenopus has a large single nephron – the functional unit of the kidney – on either side of their body. See article by Blackburn and Miller (dmm038604) to learn how Xenopus is a useful model to study kidney development and disease. Imaged by Alexandria T. M. Blackburn. Cover image is licensed under a Creative Commons Attribution 4.0 International license.
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FIRST PERSON
SPECIAL ARTICLE
One hundred years of Drosophila cancer research: no longer in solitude
Summary: This Special Article summarises the history of Drosophila as a model to understand the cancer problem, from the initial work carried out by Mary Stark 100 years ago to today.
REVIEW
Modeling congenital kidney diseases in Xenopus laevis
Summary: Understanding how congenital kidney diseases arise is imperative to their treatment. Using Xenopus as a model will aid in elucidating kidney development and congenital kidney diseases.
RESEARCH ARTICLES
Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia
Summary: The Edaraddswh/swh rat has comparable ear, nose and throat (ENT) pathology to humans with hypohidrotic ectodermal dysplasia, and prenatal correction of EDAR signalling in EdaTa mice prevents ENT disease.
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal
Summary: Our work identified the driver mutations indispensable for PDAC induction from acinar cells in mature adults and established a novel PDAC animal model with increased similarity to human disease.
Enhancing regeneration after acute kidney injury by promoting cellular dedifferentiation in zebrafish
Summary: Mortality associated with AKI is in part due to limited treatments available to ameliorate injury. The authors identify a compound that accelerates AKI recovery and promotes cellular dedifferentiation.
Characterization of high- and low-risk hepatocellular adenomas by magnetic resonance imaging in an animal model of glycogen storage disease type 1A
Summary: High-risk adenomas display magnetic resonance imaging (MRI) features clearly distinguishable from those exhibited by low-risk adenomas, suggesting the possibility of applying MRI to humans for non-invasive diagnostic purposes.
fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila
Summary: The bromodomain-containing protein FS(1)H is required in the Drosophila fat body for normal lifespan and metabolic and immune function, largely via the insulin pathway.
RESOURCE ARTICLES
CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene
Summary: The authors describe the creation of a mouse strain that reproduces a newly identified deletion mutation in a DMD patient in Russia, and present the characteristics of this new model.
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model
Editor's choice: This study describes a novel 3D cell culture model that recapitulates key features of neuropathology in synucleinopathies, including large, nuclear-associated α-synuclein and ubiquitin-positive inclusions.
PREPRINT HIGHLIGHTS
DMM Journal Meeting 2024: Pre-clinical Modelling of Human Genetic Disease and Therapy

Registration is open for our 2024 Journal Meeting. Rapid advances in gene editing and genetic technologies have revolutionised our ability to model human genetic disease and provided new hope for gene therapies. At this Meeting, speakers will present the very latest advances in modelling human genetic disease.
Moving towards heart success – Disease Models & Mechanisms Special Issue

DMM's most recent special issue compiles articles that investigate the genetic and biological mechanisms of heart failure and identify potential therapeutic strategies.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share guidance about how new technologies and different conference formats work in practice.