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Summary: DMM highlights changes in our peer-review process, and thanks peer reviewers for their involvement in this vital step in scholarly publication.

Summary: This Editorial discusses the importance of model systems with accurate face, construct, target and predictive validity for rare disease research.



Summary: In this Special Article, the author reflects on the potential of the Human Cell Atlas project for improving our understanding of disease.


Summary: Investigation of the crosstalk between the Wnt and other signaling pathways will improve understanding of orofacial cleft development and provide opportunities for treatment and prevention.


Summary: By using genetically diverse deer mice, we show that the expression of different chaperones is highly coordinated in individual animals and its profile predicts the onset of metabolic pathology.

Summary: Through a zebrafish model, this study demonstrates that leptin plays an important role in cancer-induced muscle wasting and that the leptin pathway may be a therapeutic target in cancer cachexia.

Summary: VPS13A, which is implicated in chorea-acanthocytosis, is essential for efficient lysosomal degradation, while localized in close association with mitochondria. We propose that inter-organelle communication may be relevant in the pathogenesis of the disease.

Summary: Loss of the epilepsy-related gene Frrs1l in mice causes a dramatic reduction in AMPA receptor levels at the synapse, eliciting severe motor and coordination disabilities, hyperactivity and cognitive defects, with some evidence of behavioural seizures.

Summary: Pharmacological and genetic manipulations show that endogenous serotonin inhibits axonal regeneration of individually identifiable descending neurons of lampreys after a complete spinal cord injury.

Summary: We report new humanized nematode models of amyloid-beta and apolipoprotein E gene expression, examining readouts for neurodegeneration, behavior, cellular function and survival, to elucidate the relative contributions of the proteins to the underlying pathology of Alzheimer's disease.

Summary: A liquid biopsy approach is capable of tracking early lung cancer lesions, before the adenoma-adenocarcinoma transition, in an early lung cancer mouse model driven by a KRAS mutation.

Summary: Double-hit exposure to the anti-angiogenic factor soluble fms-like tyrosine kinase and the pro-inflammatory endotoxin lipopolysaccharide in mice provides a novel, comprehensive model of pre-eclampsia, which leads to sex-specific metabolomic differences in fetuses.

Summary: ALS8/VAPB(P58S) aggregates appear to be cleared by an increase in cellular reactive oxygen species, which, in turn, triggers proteasomal degradation.

Summary: Adeno-associated-virus-mediated gene therapy for insulin receptor isoform A expression in the liver improves glucose disposal and alleviates lipid accumulation in wild-type mice under a high-fat diet.

Editor's choice: Mitochondria are conserved among eukaryotes and mutations in the factors that control their dynamics are causal for various human disorders. Hence, yeast models can be used for pharmacological screenings.


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