Issues

Summary: This Review discusses the challenges in malaria elimination and how implementation of national-scale genomic surveillance programmes in combination with resistome analyses could provide a powerful solution.

Summary: The core myopathies are neuromuscular disorders with no cure. In this Review, we outline our current understanding of pathomechanisms, the advantages and limitations of available models, and discuss emerging modeling technologies.

Summary: A zebrafish model of reticular dysgenesis reveals hair cell developmental deficits that can be partially rescued by antioxidants, pointing to their potential use as a therapeutic treatment for reticular dysgenesis patients.

Summary: Loss of Prmt5 in osteochondral progenitors impairs terminal hypertrophic chondrocyte differentiation, leading to defects in endochondral bone formation and models infantile idiopathic scoliosis in mouse.

Summary: Notch4 activation contributes to the inflammation seen in HIV-associated nephropathy (HIVAN), and inhibition of Notch4 ameliorates inflammation and prolongs life in a mouse model of HIVAN.

Summary: Here, we demonstrate the presence of a macrophage-like, CX3CL1/CX3CR1-expressing tendon cell population within the healthy tendon proper, which potentially fulfills a surveillance function.

Summary: We demonstrate that the immature gut is prone to necrotizing enterocolitis due to limited arginine/nitric oxide synthesis, leading to inadequate microcirculation in response to the challenge imposed by formula feeding.

Editor's choice: The patient-derived orthotopic xenograft model of gastroesophageal adenocarcinoma maintains the morphological and molecular characteristics despite being highly heterogeneous, emphasizing its use as a powerful investigational platform to evaluate new therapies.