Issues

Summary: This Editorial outlines how research in Drosophila has and continues to help answer complex research questions in genetics, highlighting the value of this relatively simple model organism.

Summary: This Review discusses the history and development of genome editing in non-human primates, as well as the challenges and prospects facing this technology now and in the future.

Summary: This Review discusses the different model organisms used to study cardiac regeneration and their contributions to our understanding of the complex processes that govern regeneration of the heart.

Summary: MPA may increase susceptibility to HIV-1 in sex workers through the suppression of endogenous estrogen, reducing vaginal glycogen and α-amylase levels, which increases bacterial diversity, potentially reducing protective bacterial species such as lactobacilli.

Summary: Fetal exposure to maternal inflammation alters normal development of neonatal goblet and Paneth cells, and significantly increases intestinal injury in the neonatal period through IL-6-dependent pathways.

Summary: In an oncogene-addicted liver cancer zebrafish model, transformed cancer hepatocytes could be reverted to normal hepatocytes, as shown by Cre-loxP-mediated cell-lineage tracing.

Summary: This study reports the generation of an iPSC model to investigate phenotypic changes associated with loss of SMARCAL1, as found in severe forms of the genetic disease Schimke immuno-osseous dysplasia.

Summary: Using neuronopathic Gaucher's disease iPSCs, this study has identified the mTOR complex as a potential therapeutic target in GBA1-associated neurodegeneration.

Summary: The authors developed a potent, glycoside-based inhibitor with strong ability to occlude epsilon toxin lethality both in vitro and in vivo.

Summary: The authors report Toll-6 and Spätzle as a new pair of guidance molecules mediating organ-specific metastasis behavior by activating JNK signaling, highlighting a novel role for Toll-family receptors.

Editor's choice: The RA-Shh signaling pathway is revealed to be critical during cranial neural crest development, which impacts secondary palate development.

Summary: This study shows that adult bag3 knockout mutant zebrafish can be used as a model for DCM, and haploinsufficiency of mTOR is cardioprotective.

Summary: The authors present CFIN, a deep learning-based image-analysis platform to automatically analyze dynamic light-sheet fluorescence microscopy images and determine volumetric indices of cardiac function in embryonic zebrafish.